Pharmacognostical and pharmaceutical analysis of “Medhya Rasayana”: A herbal nootropic Ayurveda formulation

Journal of Indian System of Medicine Pub Date : 2023-07-01 DOI:10.4103/jism.jism_30_23

Amisha Bavarva, V. Kori, SagarMahendrabhai Bhinde, C. Harisha, VinayJ Shukla

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Abstract

Background: Medhya Rasayana (MR) is a widely used polyherbal formulation containing Brahmi (Bacopa monneri Linn.), Shankhpushpi (Convolvulus pluricaulis Chois), Yashtimadhu (Glycyrrhiza glabra Linn.), and Guduchi (Tinospora cordifolia Wilsld Miers.). It is being used in psychological, neurological, and developmental disorders since long by Ayurveda practitioners. The pharmacopeial standards of this formulations is not available till date. Earlier few researchers had evaluated this formulation but generating consistent data of any drug is more important to reach the final quality control (QC) parameters. Hence, this study aimed to evaluate MR through pharmacognostical, physiochemical parameters and high-performance thin-layer chromatography (HPTLC) fingerprinting in the process of establishing QC data. Materials and Methods: Preauthenticated raw drugs were procured, and MR was prepared at pharmacy, ITRA, Jamnagar. Organoleptic parameters and microscopic analysis of Churna (powder) were done at pharmacognosy department, ITRA, Jamnagar. Physiochemical analysis and HPTLC of MR were done at pharmaceutical laboratory, ITRA, Jamnagar. Result: Microscopic features of MR Churna were cross-checked with Ayurvedic Pharmacopoeia of India (API) standards of individual ingredients, and it was found to have characteristics of all ingredients in it. In pharmaceutical parameters, pH value was 6.7, water-soluble extract was 9.8%w/w, methanol-soluble extract was 11.64%w/w, ash value was 8.20%w/w, and loss on drying was 4.01%w/w. HPTLC at 254 and 366 nm showed 6 and 13 spots, respectively. Conclusion: This study has generated preliminary data on pharmacognostical, pharmaceutical parameters and HPTLC in addition to reviewed available data of MR Churna. This fingerprinting along with data of previous researchers can be useful for future researchers to reproduce this formulation and to establish quality control parameters of MR Churna.

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Medhya Rasayana "的药理药效分析：阿育吠陀草药营养剂配方

背景介绍Medhya Rasayana（MR）是一种广泛使用的多草药配方，含有婆罗米（Brahmi，Bacopa monneri Linn.）、香蒲（Shankhpushpi，Convolvulus pluricaulis Chois）、Yashtimadhu（Glycyrrhiza glabra Linn.）和Guduchi（Tinospora cordifolia Wilsld Miers.）。长期以来，阿育吠陀医师一直将其用于治疗心理、神经和发育障碍。这种配方的药典标准至今尚未公布。早期有少数研究人员对这种制剂进行了评估，但任何药物要达到最终的质量控制（QC）参数，获得一致的数据更为重要。因此，本研究旨在通过药理、理化参数和高性能薄层色谱（HPTLC）指纹图谱对 MR 进行评估，以建立 QC 数据。材料和方法：采购经过鉴定的原料药，在贾姆纳加尔的 ITRA 药房制备 MR。Churna（粉末）的感官参数和显微分析在贾姆纳加尔 ITRA 的药学部完成。MR的理化分析和HPTLC在Jamnagar的ITRA制药实验室完成。结果将 MR Churna 的显微特征与《印度阿育吠陀药典》（API）中各成分的标准进行了核对，发现它具有所有成分的特征。在药物参数方面，pH 值为 6.7，水溶性提取物为 9.8%w/w，甲醇提取物为 11.64%w/w，灰分值为 8.20%w/w，干燥损失为 4.01%w/w。HPTLC 在 254 纳米和 366 纳米波长下分别显示出 6 个和 13 个斑点。结论本研究除了审查了 MR Churna 的现有数据外，还获得了有关药理、药物参数和 HPTLC 的初步数据。该指纹图谱以及之前研究人员的数据可帮助未来的研究人员复制该制剂并建立 MR Churna 的质量控制参数。

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Journal of Indian System of Medicine

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