Enhancement of Bioavailability and Bioequivalence of Drug Delivery in Sensory Neural Hearing Loss

Abstract

Sensory neural hearing loss (SNHL) is a pervasive audiological disorder characterized by damage to the inner ear's hair cells or auditory nerve. Despite extensive research efforts, SNHL treatment remains a challenge due to various barriers, including limited drug penetration into the inner ear and the risk of systemic side effects. This abstract explores the innovative use of nanoparticles in intratympanic drug delivery as a promising solution to overcome these hurdles. Nanoparticles offer a unique platform for drug delivery to the inner ear, enhancing bioavailability and ensuring bioequivalence of therapeutic agents. Through targeted delivery, controlled release, and drug protection, nanoparticles address critical limitations in traditional SNHL treatments. These abstract reviews the barriers to SNHL treatment, the advantages of nanoparticle-based delivery systems, and their potential to revolutionize the management of SNHL. Further research in this field promises to unlock new opportunities for more effective and accessible treatments for SNHL patients