Proceedings of the Toxicology and Poisons Network Australasia (TAPNA) 2023 Annual Scientific Meeting

Toxicology communications Pub Date : 2023-07-06 DOI:10.1080/24734306.2023.2222509

Rachelle Abouchedid, Sarah Hodgson, Anselm Wong, Ingrid Berling, Thomas Sullivan, Joshua Bloom, Gar Chan, Mark Su, Kate Cleary, Natasha Tile, Aisling Kiely, R. Syrjanen, Jennifer Schumann, Shaun Greene, A. Holford, Christopher Martin, Andrew Staib, Keith Harris, K. Isoardi, Benjamin Horan, Benjamin Learmont, Christina Needham, Lucy Shieffelbien, Brian O’Riordan, Jonathan Lee, Joseph Rotella, Rowena Penafiel, Gina Chowdhury, Darren M Roberts, Nazila Jamshidi, Stuart Duffin

{"title":"Proceedings of the Toxicology and Poisons Network Australasia (TAPNA) 2023 Annual Scientific Meeting","authors":"Rachelle Abouchedid, Sarah Hodgson, Anselm Wong, Ingrid Berling, Thomas Sullivan, Joshua Bloom, Gar Chan, Mark Su, Kate Cleary, Natasha Tile, Aisling Kiely, R. Syrjanen, Jennifer Schumann, Shaun Greene, A. Holford, Christopher Martin, Andrew Staib, Keith Harris, K. Isoardi, Benjamin Horan, Benjamin Learmont, Christina Needham, Lucy Shieffelbien, Brian O’Riordan, Jonathan Lee, Joseph Rotella, Rowena Penafiel, Gina Chowdhury, Darren M Roberts, Nazila Jamshidi, Stuart Duffin","doi":"10.1080/24734306.2023.2222509","DOIUrl":null,"url":null,"abstract":"Arsenicals induce their toxic effects by binding to sulfhydryl groups in multiple enzyme systems, inhibiting metabolism and disrupting oxidative phosphorylation generating reactive oxygen species. In animal studies NAC has been shown to decrease arsenic mediated oxidative damage and in in vitro studies NAC was shown to chelate arsenic. The optimal time to commence NAC therapy has not been studied, but animal studies have shown earlier treatment improved survival. Given its favourable safety profile, low cost and the findings from animal studies, NAC should be used as an adjunct to standard chelation therapy in arsenic poisoning. Further investigation is required to establish the optimal duration of treatment and dosing.","PeriodicalId":23139,"journal":{"name":"Toxicology communications","volume":"16 1","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2023-07-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Toxicology communications","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1080/24734306.2023.2222509","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}

引用次数: 0

Abstract

Arsenicals induce their toxic effects by binding to sulfhydryl groups in multiple enzyme systems, inhibiting metabolism and disrupting oxidative phosphorylation generating reactive oxygen species. In animal studies NAC has been shown to decrease arsenic mediated oxidative damage and in in vitro studies NAC was shown to chelate arsenic. The optimal time to commence NAC therapy has not been studied, but animal studies have shown earlier treatment improved survival. Given its favourable safety profile, low cost and the findings from animal studies, NAC should be used as an adjunct to standard chelation therapy in arsenic poisoning. Further investigation is required to establish the optimal duration of treatment and dosing.

查看原文本刊更多论文

澳大利亚毒理学与毒物网络（TAPNA）2023 年科学年会论文集

砷通过与多种酶系统中的巯基结合、抑制新陈代谢和破坏氧化磷酸化生成活性氧而产生毒性作用。在动物实验中，NAC 可减少砷介导的氧化损伤；在体外实验中，NAC 可螯合砷。目前尚未研究开始 NAC 治疗的最佳时间，但动物实验表明，早期治疗可提高存活率。鉴于其良好的安全性、低成本和动物实验结果，NAC 应被用作砷中毒标准螯合疗法的辅助疗法。要确定最佳治疗时间和剂量，还需要进一步的研究。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Toxicology communications

自引率

0.00%

发文量