Resistance of gastrointestinal nematoids of goats and sheep to the antihelmintics levamisol, ivermectin and albendazole

Ciência Animal Brasileira Pub Date : 2023-07-10 DOI:10.1590/1809-6891v24e-75316E

Swênia Christina Pinheiro Soares, Arnon Cunha Reis, Rogério Lean Pereira Castro, Pedro Celestino Serejo Pires, Celecina Saraiva Martins Cabral, Durval Oliveira Diniz, Camila Barros Costa, Dara Maria da Costa Pinheiro, Yasmin Suelen Alves Pinheiro, Nayla Helena Silva Buna, L. Costa, Danilo Rodrigues Barros Brito

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Abstract

Abstract The aim of this study was to determine the resistance of gastrointestinal nematodes in goats and sheep to the anthelmintic drugs levamisole, ivermectin, and albendazole in the metropolitan region of São Luís Island, Maranhão, Brazil. Fecal samples were collected from 150 animals across four different farms; two farms had goats, and the other two had sheep. The samples were then randomly divided into three to four groups of 10 animals: Group I: control, without treatment; Group II: ivermectin treatment; Group III: levamisole treatment; and Group IV: albendazole treatment. Stool samples were collected from the rectal ampulla one day before treatment and 10 days after anthelmintic treatment. Individual coproparasitological examinations were performed using the modified McMaster technique at the Animal Health Laboratory of the Federal Institute of Maranhão, Campus São Luís-Maracanã. The efficacies of the anthelmintic drugs against gastrointestinal nematodes in goats and sheep were: 14.28%, and 13.6% for ivermectin; 0% and 79.4% for levamisole; and 59.8% and 3.43% for albendazole, respectively Gastrointestinal nematodes demonstrated multiple anthelmintic resistance, as the percentage reduction in egg count was less than 95% and the lower limit of the confidence interval was less than 90%. Graphical summary

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山羊和绵羊胃肠道线虫对抗虫药左旋咪唑、伊维菌素和阿苯达唑的抗药性

摘要本研究旨在确定巴西马拉尼昂州圣路易斯岛大都会地区山羊和绵羊胃肠道线虫对抗虫药左旋咪唑、伊维菌素和阿苯达唑的耐药性。从四个不同农场的 150 只动物身上采集了粪便样本；其中两个农场饲养山羊，另外两个农场饲养绵羊。然后将样本随机分为三至四组，每组 10 头动物：第一组：对照组，不进行治疗；第二组：伊维菌素治疗组；第三组：左旋咪唑治疗组；第四组：阿苯达唑治疗组。分别在治疗前一天和治疗后 10 天从直肠肛门采集粪便样本。马拉尼昂联邦学院圣路易斯-马拉卡纳校区动物健康实验室采用改良的麦克马斯特技术对每只动物进行了共寄生虫学检查。抗蠕虫药物对山羊和绵羊胃肠道线虫的有效率分别为 14.28% 和 13.28%：伊维菌素的有效率分别为 14.28% 和 13.6%；左旋咪唑的有效率分别为 0% 和 79.4%；阿苯达唑的有效率分别为 59.8% 和 3.43% 胃肠道线虫对多种抗线虫药物具有抗药性，因为虫卵数量减少的百分比低于 95%，置信区间的下限低于 90%。图表总结

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Ciência Animal Brasileira

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