The influence of insulin resistance variables on heart rate variability indices in mature men under Russia’s North conditions

Q3 Medicine

Obesity and Metabolism Pub Date : 2023-07-27 DOI:10.14341/omet13004

I. Averyanova

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引用次数: 0

Abstract

BACKGROUND: Heart rate autonomic regulation can go out of balance which is normally assessed by the heart rate variability (HRV) indices. Similarly, it is relevant to research if and how HRV fluctuations can be influenced by varying signs of insulin resistance since they are quite common in Northern men. At present, there is no evidence of this influence in the North residents of older ages.AIM: This study aimed to comparatively assess heart rate variability in mature men who do or do not feature metabolic signs of insulin resistance.MATERIALS AND METHODS: Seventy-three mature aged male residents of Magadan Region, Caucasian by origin, were examined. All the subjects were divided into two groups: Group without insulin resistance signs (HOMA-IR index < 2.5 units) and Group with insulin resistance signs (HOMA-IR index > 2.5 units). We used immunochemiluminescent and enzymatic methods, and heart rate variability was assessed using the Varikard (Russia).RESULTS: Our research showed that 48% of all the examinees exhibited signs of insulin resistance along with an increase in the sympathetic activity in heart rate regulation. We also identified the heart rate indicators that had proved to undergo the most significant changes depending on the HOMA-IR index and the presence or absence of signs of insulin resistance: MxDMn, pNN50, SDNN, AMo50, SI, TP, HF, LF, and Body Mass.CONCLUSION: In general, the results obtained allow for ascertaining the high proportion of male Northerners of mature age with signs of insulin resistance. We also claim that those examinees demonstrate an autonomic imbalance and a moderate dominance of the sympathetic activity with a simultaneous decrease in activation of the parasympathetic link of autonomic nervous system and high body mass variables. At the same time, the correlations and causal associations among signs of insulin resistance, activation of the sympathetic link of autonomic nervous system, and overweight remain unclear. Apparently, all the analyzed features are likely to complement each other rather than completely exclude each other. The triad of obesity, signs of insulin resistance, and activation of the sympathetic link of autonomic nervous system is a driving factor for significant health risks. This study is expected to spread the use of the method of assessing heart rate variability based on insulin resistance signs as well as in reliance on metabolic disorders in general in a sample of mature men.

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胰岛素抵抗变量对俄罗斯北方成熟男性心率变异指数的影响

背景：心率自律调节可能会失去平衡，这通常可以通过心率变异性（HRV）指数来评估。同样，研究胰岛素抵抗的不同表现是否会影响心率变异性波动以及如何影响心率变异性波动也很有意义，因为胰岛素抵抗在北方男性中很常见。材料和方法：研究对象为马加丹地区 73 名高加索裔成年男性居民。所有受试者分为两组：无胰岛素抵抗症状组（HOMA-IR 指数小于 2.5 单位）和有胰岛素抵抗症状组（HOMA-IR 指数大于 2.5 单位）。结果：我们的研究表明，48% 的受试者表现出胰岛素抵抗症状，同时心率调节中交感神经活动增加。我们还确定了根据 HOMA-IR 指数和胰岛素抵抗迹象的存在与否而发生最显著变化的心率指标：结论：总体而言，研究结果表明，在北方男性成熟人群中，有胰岛素抵抗迹象的比例很高。我们还发现，这些受检者的自律神经失衡，交感神经活动适度占主导地位，同时自律神经系统副交感神经环节的激活减少，体质变量较高。同时，胰岛素抵抗迹象、自律神经系统交感神经环节的激活和超重之间的相关性和因果关系仍不清楚。显然，所有分析的特征都可能相互补充，而不是完全排斥。肥胖、胰岛素抵抗迹象和自主神经系统交感环节的激活这三者是导致重大健康风险的驱动因素。这项研究有望在成熟男性样本中推广使用基于胰岛素抵抗迹象的心率变异性评估方法，以及对一般代谢紊乱的依赖。

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来源期刊

Obesity and Metabolism Medicine-Internal Medicine

CiteScore

1.30

自引率

0.00%

发文量

期刊介绍： Journal "Obesity and Metabolism" is a multidisciplinary forum for clinical and applied research in the field of biochemistry, physiology, pathophysiology, genetics, nutrition, as well as molecular, metabolic, psychological and epidemiological aspects of obesity and metabolism. The main subject "Metabolism" reviewed in the journal, includes fat, carbohydrate, protein, bone, fluid and electrolyte and other types of metabolism in the spectrum of pathology of the endocrine system. The priority direction of Journal "Obesity and Metabolism" is publishing modern high-quality original research on the effectiveness of new and existing treatments in any aspect of metabolic and endocrine diseases. Pre-clinical pharmacology, pharmacokinetics studies, meta-analyzes, addressed to drug safety and tolerance are also welcome for publication in the journal "Obesity and metabolism." Journal "Obesity and Metabolism" announces review articles that are balanced, clear and offer the reader a modern and critical analysis of the literature on the subject of the magazine. Case reports, and lecture materials are also published for highlighting for practitioners new approaches to diagnosis and treatment of patients with metabolic disorders and obesity.