Hekzaklorosiklotrifosfazen ile Yeni Bir N-İkame Edilmiş Aminoalkol Türevinin Tasarımı ve Sentezi

Abstract

Hexachlorocyclotriphosphazene, N3P3Cl6, are cyclical and give substitution reactions with amines, alcohols, etc., nucleophiles. Nucleophilic substitution reactions of cyclotriphosphazene with bifunctional nucleophiles such as diols, diamines and aminoalcohols have been a subject of intense study over decades. Due to the stable P=N bond in phosphazenes, phosphazene derivatives can have properties such as resistance to heat, radiation, combustion, reducing and oxidizing substances. Cyclophosphazene derivatives usually have biological compatibility and degrade into non-toxic small molecules, thus are advantageous to biological activities and DNA interactions. For this reason, the properties of cyclic phosphazene compounds, anticarcinogenic, antibacterial and DNA interactions are currently studied topics. The condensation reactions of N/O donor type bifunctional N-substituted aminoalcohols with hexachlorocyclotriphosphazene were investigated and the spiro-cyclic tetrachlorocyclotriphosphazene derivatives (1 - 4) were prepared. Elemental analyses, ESI-MS, FT-Raman, FTIR and NMR spectroscopy techniques were employed to characterize all of the compounds.