Student Competition (Technology Innovation) ID 1984861

IF 2.4 Q1 REHABILITATION
Soroush Mirkiani, Neil Tyreman, Carly L O’Sullivan, Don Wilson, Amin Arefadib, Richard Fox, Philip Troyk, Vivian K. Mushahwar
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引用次数: 0

Abstract

Intraspinal microstimulation (ISMS) is a neuromodulation technique for restoring walking after spinal cord injury. The objective of this study was to fabricate a stretchable ISMS device suitable for pigs, a clinically-relevant animal model. Polyimide-insulated microwires (50µm, Pt-Ir, 80%/20%) were used for fabrication of electrodes. Their tips were de-insulated (∼0.15mm2) and sharpened using nanosecond and femtosecond UV lasers. Microcoils were fabricated from 25μm microwires (Pt-Ir, 80%/20%) to add stretchability to the lead wires. Sixteen microelectrode-leads were connected to a custom, wirelessly controlled stimulator using Medtronic extension cables (Model 37081). The implants were tested in seven domestic pigs and current pulse trains were delivered to various rostro-caudal regions of the lumbar spinal cord (1s, 40Hz, 50µA-300µA) to activate locomotor-related muscle synergies. The kinematics and isometric joint forces of the evoked hindlimb responses were recorded. Graded joint movements were evoked with increasing stimulus amplitude. Changes in the hip, knee, and ankle joints angles evoked by ISMS at 300µA were 17.9±1˚, 28.1±1˚, and 21.6±2˚, respectively. Isometric joint forces evoked by ISMS at 300µA were 12.21±0.91N, 7.4±0.71N, and 1.7±0.15N for knee extension, hip flexion, and ankle flexion, respectively. The movements evoked using the developed ISMS implant could generate full ranges of motion in the joints. The graded responses imply a near-physiological recruitment order of motoneurons, which is necessary for achieving long walking distances without muscle fatigue. The results show the capability of the developed ISMS device in generating movements in pigs, and the implants’ potential for future use in humans.
学生竞赛(技术创新) ID 1984861
脊髓内微刺激(ISMS)是一种用于恢复脊髓损伤后行走能力的神经调控技术。本研究的目的是制造一种适用于临床相关动物模型猪的可拉伸椎管内微刺激装置。 制作电极时使用了聚酰亚胺绝缘微线(50 微米,铂-铁,80%/20%)。使用纳秒和飞秒紫外激光对其尖端进行去绝缘处理(∼0.15mm2)和锐化处理。微线圈由 25 微米的微导线(铂-铁,80%/20%)制成,以增加导线的伸展性。使用美敦力公司的延长线(37081 型)将 16 根微电极导线连接到定制的无线控制刺激器上。 在七只家猪身上对植入物进行了测试,并向腰部脊髓的不同喙尾区域(1 秒,40Hz,50µA-300µA)输送电流脉冲序列,以激活与运动相关的肌肉协同作用。记录诱发的后肢反应的运动学和等长关节力。 随着刺激振幅的增大,诱发了分级关节运动。300µA的ISMS诱发的髋关节、膝关节和踝关节角度变化分别为17.9±1˚、28.1±1˚和21.6±2˚。ISMS 在 300µA 下诱发的伸膝、屈髋和屈踝关节等长关节力分别为 12.21±0.91N、7.4±0.71N 和 1.7±0.15N。 使用所开发的 ISMS 植入体诱发的运动可以在关节中产生全范围的运动。分级反应意味着运动神经元的募集顺序接近生理水平,这对于实现无肌肉疲劳的长距离行走是必要的。研究结果表明,所开发的 ISMS 装置具有在猪身上产生运动的能力,而且这种植入物将来有可能用于人类。
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来源期刊
CiteScore
3.20
自引率
3.40%
发文量
33
期刊介绍: Now in our 22nd year as the leading interdisciplinary journal of SCI rehabilitation techniques and care. TSCIR is peer-reviewed, practical, and features one key topic per issue. Published topics include: mobility, sexuality, genitourinary, functional assessment, skin care, psychosocial, high tetraplegia, physical activity, pediatric, FES, sci/tbi, electronic medicine, orthotics, secondary conditions, research, aging, legal issues, women & sci, pain, environmental effects, life care planning
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