Comparative estimation of C-terminal cross-linked telopeptide of type I collagen levels in gingival crevicular fluid in diabetic and nondiabetic patients with chronic periodontitis: A prospective clinical study

IF 0.5 Q4 DENTISTRY, ORAL SURGERY & MEDICINE

Journal of International Oral Health Pub Date : 2023-09-01 DOI:10.4103/jioh.jioh_135_23

Anushree Ningombam, Nipun Dhalla, P. Palwankar, Anjana Goyal, Ruchi Pandey

{"title":"Comparative estimation of C-terminal cross-linked telopeptide of type I collagen levels in gingival crevicular fluid in diabetic and nondiabetic patients with chronic periodontitis: A prospective clinical study","authors":"Anushree Ningombam, Nipun Dhalla, P. Palwankar, Anjana Goyal, Ruchi Pandey","doi":"10.4103/jioh.jioh_135_23","DOIUrl":null,"url":null,"abstract":"Aim: To estimate C-terminal cross-linked telopeptide (CTx) levels in GCF, using ELISA in diabetic and nondiabetic patients with chronic periodontitis. Materials and Methods: A total of 42 patients were recruited: 21 type II diabetic patients with chronic periodontitis (group A) and 21 nondiabetic patients with chronic periodontitis (group B). Scaling and root planing (SRP) were done in groups, followed by collection of GCF samples and recording of clinical variables. Measurements for clinical indicators of periodontal health were taken on 0 day (baseline), first and after third month. The Ctx level of GCF was taken at baseline and after 3 months using enzyme-linked immunosorbent assay (ELISA). GPower software (version 3.0) was used. Paired t tests and Student’s t tests as well as parametric tests were used to analyze the results. The threshold for significance was fixed at P < 0.05. Result: Following SRP, there was a significant reduction in Ctx levelsand an improvement in clinical parameters in both groups. There is a negative correlation uniting CTx quantity with an improvement in periodontal conditions in both diabetic and nondiabetic patients. Conclusion: CTx levels in both diabetic and nondiabetic candidates with chronic periodontitis infection were reduced after nonsurgical periodontal therapy.","PeriodicalId":16138,"journal":{"name":"Journal of International Oral Health","volume":"278 1","pages":"463 - 468"},"PeriodicalIF":0.5000,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of International Oral Health","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.4103/jioh.jioh_135_23","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"DENTISTRY, ORAL SURGERY & MEDICINE","Score":null,"Total":0}

引用次数: 0

Abstract

Aim: To estimate C-terminal cross-linked telopeptide (CTx) levels in GCF, using ELISA in diabetic and nondiabetic patients with chronic periodontitis. Materials and Methods: A total of 42 patients were recruited: 21 type II diabetic patients with chronic periodontitis (group A) and 21 nondiabetic patients with chronic periodontitis (group B). Scaling and root planing (SRP) were done in groups, followed by collection of GCF samples and recording of clinical variables. Measurements for clinical indicators of periodontal health were taken on 0 day (baseline), first and after third month. The Ctx level of GCF was taken at baseline and after 3 months using enzyme-linked immunosorbent assay (ELISA). GPower software (version 3.0) was used. Paired t tests and Student’s t tests as well as parametric tests were used to analyze the results. The threshold for significance was fixed at P < 0.05. Result: Following SRP, there was a significant reduction in Ctx levelsand an improvement in clinical parameters in both groups. There is a negative correlation uniting CTx quantity with an improvement in periodontal conditions in both diabetic and nondiabetic patients. Conclusion: CTx levels in both diabetic and nondiabetic candidates with chronic periodontitis infection were reduced after nonsurgical periodontal therapy.

查看原文本刊更多论文

糖尿病和非糖尿病慢性牙周炎患者牙龈缝隙液中 I 型胶原蛋白 C 端交联端肽水平的比较估计：前瞻性临床研究

目的：使用酶联免疫吸附法评估糖尿病和非糖尿病慢性牙周炎患者 GCF 中 C 端交联端肽 (CTx) 的水平。材料和方法：共招募了 42 名患者：21 名患有慢性牙周炎的 II 型糖尿病患者（A 组）和 21 名患有慢性牙周炎的非糖尿病患者（B 组）。分组进行洗牙和根面平整（SRP），然后收集 GCF 样本并记录临床变量。牙周健康临床指标的测量分别在 0 天（基线）、第一个月和第三个月后进行。在基线和 3 个月后，使用酶联免疫吸附试验（ELISA）检测 GCF 的 Ctx 水平。使用 GPower 软件（3.0 版）。使用配对 t 检验和学生 t 检验以及参数检验来分析结果。显著性阈值定为 P <0.05。结果SRP治疗后，两组患者的Ctx水平均明显下降，临床指标也有所改善。糖尿病和非糖尿病患者的 CTx 数量与牙周状况的改善呈负相关。结论非手术牙周治疗后，患有慢性牙周炎感染的糖尿病和非糖尿病患者的 CTx 水平都有所降低。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Journal of International Oral Health Dentistry-Dentistry (all)

CiteScore

1.00

自引率

14.30%

发文量

期刊介绍： It is a journal aimed for research, scientific facts and details covering all specialties of dentistry with a good determination for exploring and sharing the knowledge in the medical and dental fraternity. The scope is therefore huge covering almost all streams of dentistry - starting from original studies, systematic reviews, narrative reviews, very unique case reports. Our journal appreciates research articles pertaining with advancement of dentistry. Journal scope is not limited to these subjects and is more wider covering all specialities of dentistry follows: Preventive and Community Dentistry (Dental Public Health) Endodontics Oral and Maxillofacial Pathology Oral and Maxillofacial Radiology Oral and Maxillofacial Surgery (also called Oral Surgery) Orthodontics and Dentofacial Orthopaedics Periodontology (also called Periodontics) Pediatric Dentistry (also called Pedodontics) Prosthodontics (also called Prosthetic Dentistry) Oral Medicine Special Needs Dentistry (also called Special Care Dentistry) Oral Biology Forensic Odontology Geriatric Dentistry or Geriodontics Implantology Laser and Aesthetic Dentistry.