Isolation of new bibenzyl derivatives from Bulbophyllum auricomum and evaluation of their α-glucosidase inhibitory activity

IF 0.9 Q4 CHEMISTRY, MEDICINAL

Journal of Biologically Active Products from Nature Pub Date : 2023-09-03 DOI:10.1080/22311866.2023.2286246

Hoo Tint San, Ne Yi Hla, Ei Mon Hla, C. Chansriniyom, B. Sritularak, K. Likhitwitayawuid

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Abstract

Abstract Bulbophyllum auricomum Lindl., commonly referred to as the 'Royal Thazin' in Myanmar, holds the esteemed status of being the national flower of the country. In our research, we delved into the ethyl acetate extract derived from the pseudobulbs and roots of this plant. This extract exhibited significant inhibitory activity against the α-glucosidase enzyme, prompting a detailed investigation into its active compounds. Our study resulted in the isolation and characterization of several compounds, including a novel natural product named 2-(4-hydroxyphenyl) ethyl 3-(2-hydroxyphenyl) propanoate. Additionally, we identified two previously unreported inseparable isomeric bibenzyls, namely 7-hydroxybatatasin III and 8-hydroxybatatasin III. Furthermore, we isolated six known compounds, including batatasin III, lusianthridin, tristin, phochinenin G, phoyunnanin E, and phoyunnanin C. Significantly, our study unveiled that phochinenin G acts as a reversible noncompetitive inhibitor of the α-glucosidase enzyme. This compound displayed greater inhibitory activity than the standard drug acarbose. GRAPHICAL ABSTRACT

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从牛肝菌中分离出新的苄基衍生物并评估其α-葡萄糖苷酶抑制活性

摘要 Bulbophyllum auricomum Lindl.在缅甸通常被称为 "Royal Thazin"，具有国花的崇高地位。在研究中，我们深入研究了从这种植物的假鳞茎和根中提取的乙酸乙酯提取物。这种提取物对α-葡萄糖苷酶有明显的抑制作用，促使我们对其活性化合物进行了详细研究。通过研究，我们分离并鉴定了几种化合物，包括一种名为 2-（4-羟基苯基）乙基 3-（2-羟基苯基）丙酸酯的新型天然产物。此外，我们还发现了两种以前未报道过的不可分离的异构体双苄，即 7-hydroxybatatasin III 和 8-hydroxybatatasin III。此外，我们还分离出了六种已知的化合物，包括巴旦木素 III、卢桑苷、三尖杉素、辛夷苷 G、辛夷苷 E 和辛夷苷 C。该化合物的抑制活性高于标准药物阿卡波糖。图表摘要

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来源期刊

Journal of Biologically Active Products from Nature Agricultural and Biological Sciences-Agricultural and Biological Sciences (miscellaneous)

CiteScore

2.10

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