Effectiveness of Nifedipine in the Treatment of Threathened Preterm Labour

Abstract

Background: Preterm birth is one of the most important and major causes of perinatal morbidity and mortality wordwide. Strategies should be adopted to decrease the incidence of pre-term labour and delivery to avoid the associated drastic fetal and neonatal consequences. Objective: To evaluate the effectiveness of Nifedipine in the treatment of spontaneous preterm labour. Material and Methods: This is a Randomised control trial which was conducted in the department of Obstetrics and Gynecology, Hayatabad Medical Complex, from 1st June 2022 to 30th November 2022. Total 50 pregnant women with singleton pregnancy with threatened preterm labor between 28 and 34 weeks of pregnancy on LMP were included.Results: Total 10 (20.0%) patients had a delay in delivery up to < 2 days while 40 (80.0%) patients had a delay in their deliveries for > 2 days, therefore, effectiveness of Nifedipine in the treatment of spontaneous threatened preterm labor was achieved in 40 (80%) patients in terms of delay in their deliveries. Conclusion: This study demonstrated that Nifedipine successfully delayed spontaneous preterm labor for > 48 hours and thus gave sufficient time for in utero transfer and corticosteroid effect.Keywords: Nifedipine, Preterm labor, Tocolysis.