A 2023 NOBEL PRIZE IN PHYSIOLOGY OR MEDICINE: PATHWAY FOR NEXT GENERATION OF VACCINES

IF 0.3 4区农林科学 Q4 VETERINARY SCIENCES

Slovenian Veterinary Research Pub Date : 2023-09-30 DOI:10.26873/svr-1879-2023

Klementina Fon Tacer, U. Rajčevič

{"title":"A 2023 NOBEL PRIZE IN PHYSIOLOGY OR MEDICINE: PATHWAY FOR NEXT GENERATION OF VACCINES","authors":"Klementina Fon Tacer, U. Rajčevič","doi":"10.26873/svr-1879-2023","DOIUrl":null,"url":null,"abstract":"This year’s Nobel Prize in Physiology or Medicine has been awarded to Katalin Karikó and Drew Weissman for discoveries that enabled the development of messenger RNA (mRNA) vaccines against COVID-19. mRNA is a transient molecule in the cell that conveys the instructions for synthesis of a protein from the nucleus, where instructions are stored as a genetic code in the DNA, to the cell’s protein making machinery (ribosomes) in the cytoplasm. It took several decades of research to uncover how mRNA could be used to deliver an antigen into cells and trigger the body’s own immune response. NOBELOVA NAGRADA 2023 ZA FIZIOLOGIJO ALI MEDICINO: POT DO NASLEDNJEGA RODU CEPIV Letošnja Nobelova nagrada za fiziologijo ali medicino je bila podeljena Katalin Karikó in Drewu Weissmanu za odkritja, ki so omogočila razvoj cepiv proti COVID-19 na osnovi sporočilne RNA (mRNA). mRNA je prehodna molekula v celici, ki posreduje navodila za sintezo proteinov iz jedra, kjer so navodila shranjena kot genetski kod v DNA, celičnemu sistemu za izdelovanje proteinov (ribosomov) v citoplazmi. Potrebnih je bilo več desetletij raziskav, da bi odkrili, kako uporabiti mRNA za prenos antigenov celicam in začetek telesu lastnega imunskega odziva. Ključne besede: Nobelova nagrada; mRNA cepiva; genska terapija","PeriodicalId":21765,"journal":{"name":"Slovenian Veterinary Research","volume":"230 1","pages":""},"PeriodicalIF":0.3000,"publicationDate":"2023-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Slovenian Veterinary Research","FirstCategoryId":"97","ListUrlMain":"https://doi.org/10.26873/svr-1879-2023","RegionNum":4,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"VETERINARY SCIENCES","Score":null,"Total":0}

引用次数: 0

Abstract

This year’s Nobel Prize in Physiology or Medicine has been awarded to Katalin Karikó and Drew Weissman for discoveries that enabled the development of messenger RNA (mRNA) vaccines against COVID-19. mRNA is a transient molecule in the cell that conveys the instructions for synthesis of a protein from the nucleus, where instructions are stored as a genetic code in the DNA, to the cell’s protein making machinery (ribosomes) in the cytoplasm. It took several decades of research to uncover how mRNA could be used to deliver an antigen into cells and trigger the body’s own immune response. NOBELOVA NAGRADA 2023 ZA FIZIOLOGIJO ALI MEDICINO: POT DO NASLEDNJEGA RODU CEPIV Letošnja Nobelova nagrada za fiziologijo ali medicino je bila podeljena Katalin Karikó in Drewu Weissmanu za odkritja, ki so omogočila razvoj cepiv proti COVID-19 na osnovi sporočilne RNA (mRNA). mRNA je prehodna molekula v celici, ki posreduje navodila za sintezo proteinov iz jedra, kjer so navodila shranjena kot genetski kod v DNA, celičnemu sistemu za izdelovanje proteinov (ribosomov) v citoplazmi. Potrebnih je bilo več desetletij raziskav, da bi odkrili, kako uporabiti mRNA za prenos antigenov celicam in začetek telesu lastnega imunskega odziva. Ključne besede: Nobelova nagrada; mRNA cepiva; genska terapija

查看原文本刊更多论文

2023 年诺贝尔生理学或医学奖：下一代疫苗之路

今年的诺贝尔生理学或医学奖授予了卡塔林-卡里科（Katalin Karikó）和德鲁-魏斯曼（Drew Weissman），以表彰他们开发出针对 COVID-19 的信使核糖核酸（mRNA）疫苗。mRNA 是细胞中的一种瞬时分子，它将合成蛋白质的指令从储存在 DNA 中作为遗传密码的细胞核传递到细胞质中的蛋白质制造机制（核糖体）。经过数十年的研究，我们才发现如何利用 mRNA 将抗原传递到细胞中并触发人体自身的免疫反应。2023 年诺贝尔生理学或医学奖：通往下一代疫苗的途径今年的诺贝尔生理学或医学奖授予了卡塔林-卡里科（Katalin Karikó）和德鲁-魏斯曼（Drew Weissman），以表彰他们在开发基于信使核糖核酸（mRNA）的 COVID-19 疫苗方面的发现。mRNA 是细胞中的一种瞬时分子，它将蛋白质合成指令从存储为遗传密码的 DNA 的细胞核传递到细胞质中的细胞蛋白质制造系统（核糖体）。经过几十年的研究，我们才发现如何利用 mRNA 将抗原转移到细胞中，并触发人体自身的免疫反应。关键词诺贝尔奖；mRNA 疫苗；基因疗法

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Slovenian Veterinary Research VETERINARY SCIENCES-

CiteScore

0.60

自引率

0.00%

发文量

审稿时长

>12 weeks

期刊介绍： SLOVENIAN VETERINARY RESEARCH (ISSN 1580-4003) publishes original articles, which report the results of original research in most areas of biomedicine. The journal also publishes review articles dealing with rapidly developing areas of biomedicine or which update understanding of classical fields of biomedicine, as well as case reports, shorter scientific contributions, letters to the editor, etc.; which have not been published or are under consideration for publication elsewhere. Only papers written in English can be considered.