Prognostic Significance of Hematological Parameters in Hospitalized Elderly with COVID-19

Abstract

Background/Aim: COVID-19 is a global pandemic; it caused more than 256 million cases, early detection of patients at high risk of mortality is of great importance in saving lives of COVID-19 patients. “In our study” we aimed to utilize the hematological parameters in predicting prognosis and mortality among elderly patients diagnosed with COVID19 infection admitted at Geriatric isolation hospital, Ain Shams University during the period from 26/12/2020 to 20/6/2021. Methods : This is a retrospective cohort study involving elderly patients admitted at Geriatric isolation hospital, Ain Shams University during the period from 26/12/2020 to 20/6/2021.Retrospective evaluation of medical records was used to collect data. The study included patients older than 60 years with proof of SAR-CoV2 by nasopharyngeal swab. Serial complete blood count parameters were reported during admission: hemoglobin (Hb), Total leukocytic count (TLC), Neutrophils (N), lymphocytes (L), platelets (PLT), Red Cell Distribution Width (RDW), Neutrophil/lymphocyte(NLR), platelet/lymphocyte(PLR) ratios were calculated, other hematological parameters as C-reactive protein (CRP) and ferritin were reported. Results : Among 50 hospitalized COVID 19 patients with mean age of 68.5 years, 54% were males. Mortality of those patients has statistically significant association with presence of high NLR, CRP, Ferritin and lymphopenia on admission and the likelihood of patients’ mortality will rise with presence of NLR>12.4, CRP>120mg/L, FERRITIN>493.6mcg/L and Lymphocytes≤0.88 *10 9/ L on admission, however, presence of CRP>120mg/L is an independent factor for mortality in hospitalized elderly with COVID 19. Conclusion : Hematological parameters as (NLR, CRP, Ferritin and lymphopenia) are predictor markers for mortality in hospitalized elderly with COVID-19.