Mental health symptoms and illness trajectory following COVID-19 hospitalization: A cohort study

IF 1 Q4 CARDIAC & CARDIOVASCULAR SYSTEMS
Harriet Lomholt-Welch, A. Morrow, R. Sykes, Merna Saleh, Baryab Zahra, Alasdair MacIntosh, Anna Kamdar, Catherine Bagot, Hannah Bayes, Kevin Blyth, H. Bulluck, D. Carrick, Colin Church, D. Corcoran, Iain Findlay, V. Gibson, L. Gillespie, D. Grieve, Pauline Barrientos, Antonia Ho, Ninian N Lang, David Lowe, V. Lennie, Peter Macfarlane, Kaitlin J. Mayne, Patrick B. Mark, A. Mcconnachie, R. McGeoch, Sabrina Nordin, Alexander Payne, Alastair Rankin, K. Robertson, N. Ryan, Giles Roditi, Naveed Sattar, D. Stobo, Sarah Allwood-Spiers, R. Touyz, G. Veldtman, S. Weeden, R. Weir, S. Watkins, P. Welsh, K. Mangion, Colin Berry
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引用次数: 0

Abstract

Background: The multisystem associations between baseline mental health status and coronavirus disease-19 (COVID)-19 illness trajectory are uncertain. Objectives: This article will investigate the associations between baseline mental health status and disease trajectory following COVID-19 hospitalization, which may have implications for practice and future research. Methods: The Chief Scientist Office Cardiovascular and Pulmonary Imaging in severe acute respiratory syndrome (SARS) COVID-19 study is a prospective, observational, multicenter, longitudinal, secondary care cohort study that assessed the time-course of multi-organ injury in posthospital survivors of COVID-19. Patients were assessed in-hospital, at 28–60 days after discharge and in the longer term using electronic health record linkage. Results: One hundred and fifty-two patients (mean ± standard deviation [SD] age 54.3 ± 11.8 years, 43% female, 40% most socio-economically deprived quintile, 33% history of mental health history) were enrolled and had mental health serially assessed using the Patient Health Questionnaire-4 (PHQ-4) questionnaire. Fifty-three (35%) had PHQ-4 score of 6–12 consistent with moderate-severe symptoms of anxiety or depression and this was associated with diagnostic criteria for myocarditis (P = 0.0498). Moderate-severe symptoms of anxiety or depression were positively associated with higher perception of illness, lower health-related quality of life (HRQoL), and poorer physical function. The mean (SD) duration of follow-up after hospital discharge was 428 (86) days (range, 290–627 days). PHQ-4 score was not associated with clinical outcomes at follow-up. Conclusions: In patients who have been hospitalized with COVID-19, moderate-severe symptoms of anxiety or depression were associated with myocarditis, worse HRQoL, higher perception of illness, and lower levels of physical function. Public Registration: ClinicalTrials.gov identifier is NCT04403607.
COVID-19 住院治疗后的精神健康症状和疾病轨迹:一项队列研究
背景:基线心理健康状况与19型冠状病毒病(COVID)-19发病轨迹之间的多系统关联尚不确定。目的:本文将研究基线精神健康状况与冠状病毒疾病-19(COVID-19)发病轨迹之间的关系:本文将研究基线心理健康状况与 COVID-19 住院后的疾病轨迹之间的关联,这可能对实践和未来研究产生影响。研究方法严重急性呼吸系统综合征(SARS)COVID-19 首席科学家办公室心血管和肺部成像研究是一项前瞻性、观察性、多中心、纵向、二级护理队列研究,旨在评估 COVID-19 住院后幸存者多器官损伤的时间进程。通过电子病历链接对患者在院内、出院后 28-60 天以及更长期的情况进行评估。结果:152名患者(平均±标准差[SD]年龄为54.3±11.8岁,43%为女性,40%为社会经济最贫困的五分之一人口,33%有精神疾病史)接受了登记,并使用患者健康问卷-4(PHQ-4)对其精神健康状况进行了连续评估。53人(35%)的PHQ-4得分在6-12分之间,符合中重度焦虑或抑郁症状,这与心肌炎的诊断标准有关(P = 0.0498)。中度严重焦虑或抑郁症状与较高的疾病感知、较低的健康相关生活质量(HRQoL)和较差的身体功能呈正相关。出院后的平均(标清)随访时间为 428 (86) 天(范围为 290-627 天)。PHQ-4 评分与随访时的临床结果无关。结论在因 COVID-19 而住院的患者中,中度-重度焦虑或抑郁症状与心肌炎、较差的 HRQoL、较高的疾病感知和较低的身体功能水平有关。公开注册:ClinicalTrials.gov 识别码为 NCT04403607。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
CiteScore
1.10
自引率
0.00%
发文量
10
审稿时长
19 weeks
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