Clinical significance of micronutrient status and vaginal microbiocenosis in pregnant women and correction of indentified disorders

Y. V. Kukharchyk, L. Gutikova
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Abstract

Objective: to conduct a clinical analysis and evaluate the significance of micronutrient status and vaginal microbiocenosis in pregnant women and develop a method for correcting the identified disorders based on the use of Bellakt Mama+ powdered milk product.   Materials and methods. We conducted a prospective study on the basis of the professorial advisory center of the EE “Grodno State Medical University”. In the course of the work, we examined 110 pregnant women, 55 of whom took Bellakt MAMA + dry milk product for 3 months, and the second half were observed only according to the clinical protocol. The assessment was made: anamnestic - assessment of the anamnesis of life and disease; generally accepted clinical, laboratory and instrumental (ultrasound examination of the pelvic organs) research methods. Performed blood sampling from the cubital vein in the morning on an empty stomach with the determination of the levels of ferritin, calcium i, iron, total vitamin D, folic acid, osteocalcin. An assessment of the biocoenosis of the urogenital tract was carried out “Femoflor Screen”; statistical processing of the results was carried out.   Results. We found that in patients who took a dry dairy product of Belarusian production, a persistent positive trend in the increase in the level of folic acid (p = 0,0049), total vitamin D (p = 0,0041), serum iron (p = 0,0041) was established, ferritin (p = 0,0040), as well as improvement of the vaginal biocoenosis (p = 0,0040). There were no statistically significant differences in the levels of ionized calcium and osteocalcin. It should be noted that the patients of the main group had no complaints of discomfort in large joints, bones and cramps in the calf muscles, in contrast to the women of the control group.   Conclusion. The above results confirm the need to control and correct micronutrient deficiency and vaginal dysbiosis in women at the stage of preconception preparation and in the first trimester of pregnancy.
孕妇微量营养素状况和阴道微生物菌群失调的临床意义以及对已发现疾病的纠正
目的:进行临床分析,评估孕妇微量营养素状况和阴道微生物致病的意义,并根据 Bellakt Mama+ 奶粉产品的使用情况,制定纠正已发现疾病的方法。 材料和方法。我们在 "格罗德诺国立医科大学 "EE教授咨询中心的基础上开展了一项前瞻性研究。在工作过程中,我们对110名孕妇进行了检查,其中55人服用了3个月的 "Bellakt MAMA+"干奶粉,另一半人仅根据临床方案进行了观察。评估方法包括:病史评估--生活和疾病的病史评估;公认的临床、实验室和仪器(盆腔器官超声波检查)研究方法。早上空腹从肘静脉采血,测定铁蛋白、钙、铁、总维生素 D、叶酸和骨钙素的水平。进行了 "Femoflor 筛选",对泌尿生殖道的生物特征进行了评估;对结果进行了统计处理。 结果我们发现,在服用白俄罗斯生产的干乳制品的患者中,叶酸(p = 0.0049)、总维生素 D(p = 0.0041)、血清铁(p = 0.0041)、铁蛋白(p = 0.0040)的水平呈持续上升趋势,阴道生物钙化也有所改善(p = 0.0040)。离子钙和骨钙素的水平没有明显的统计学差异。值得注意的是,与对照组的妇女相比,主要治疗组的患者没有出现大关节、骨骼不适和小腿肌肉抽筋的症状。 结论上述结果证实,有必要在孕前准备阶段和怀孕头三个月控制和纠正妇女的微量元素缺乏症和阴道菌群失调症。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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