COVID-19 Infection and the Preeclampsia in Pregnant Women

Q4 Medicine

Indonesian Journal of Obstetrics and Gynecology Pub Date : 2023-10-26 DOI:10.32771/inajog.v11i4.1796

Cindy M. Pradana, D. D. Parti, Elly N. Sakinah

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引用次数: 0

Abstract

Objective: To determine the relationship between COVID-19 infection and preeclampsia in pregnant women at RSD dr. Soebandi Jember. Methods: This study used cross-sctional study with simple random sampling. The data is secondary data from medical records of 118 pregnant women who checked their pregnancies from March 2020 to December 2021 at RSD dr. Soebandi Jember and analyzed with chi-square test and logistic regression test. Results: Multivariate analysis showed that there were a relationship between COVID-19 infection with preeclampsia. COVID-19 is the most risky variable with an OR of 4.045 (95% CI 1.595 – 10.259). This condition happens because COVID-19 infection triggers down-regulation of RAS which make the failure of spiral artery remodelling and preeclampsia. Conclusion: There is a relationship between COVID-19 infection and the incidence of preeclampsia in RSD dr. Soebandi Jember. Keywords: COVID-19, preeclampsia, renin-angiotensin system (RAS), SARS-CoV-2 Abstrak Tujuan: Untuk mengetahui hubungan antara infeksi COVID-19 dengan kejadian preeklamsia pada ibu hamil di RSD dr. Soebandi Jember. Metode: Penelitian ini merupakan studi potong lintang dengan pengambilan sampel menggunakan simple random sampling. Penelitian ini menggunakan data sekunder rekam medis 118 ibu hamil yang memeriksakan kehamilannya mulai Maret 2020 hingga Desember 2021 di RSD dr. Soebandi Jember dan dianalisa dengan uji statistik Chi-square dan uji regresi logistik. Hasil: Analisis statistik menunjukkan terdapat hubungan antara infeksi COVID-19, usia, dan obesitas dengan kejadian preeklamsia di RSD dr. Soebandi Jember. Variabel COVID-19 merupakan variabel yang paling berisiko terhadap terjadinya preeklampsia dengan OR 4,045 (95% CI 1,595 – 10,259). Hal ini terjadi karena infeksi COVID-19 memicu down-regulasi pada RAS yang mengakibatkan kegagalan remodelling arteri spiralis dan preeklamsia Kesimpulan: Terdapat hubungan antara infeksi COVID-19 dengan kejadian preeklamsia di RSD dr. Soebandi Jember. Kata kunci: COVID-19, preeklamsia, renin-angiotensin system (RAS), SARS-CoV-2

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COVID-19 感染与孕妇先兆子痫

目的确定 Soebandi Jember RSD 医生处孕妇 COVID-19 感染与先兆子痫之间的关系。研究方法本研究采用简单随机抽样的交叉性研究。数据来自于苏班迪-詹伯医生中心（RSD dr. Soebandi Jember）2020 年 3 月至 2021 年 12 月期间 118 名孕妇的医疗记录，并通过卡方检验（chi-square test）和逻辑回归检验（logistic regression test）进行分析。结果显示多变量分析表明，COVID-19感染与子痫前期之间存在关系。COVID-19是最危险的变量，OR值为4.045（95% CI 1.595 - 10.259）。出现这种情况的原因是 COVID-19 感染引发了 RAS 下调，导致螺旋动脉重塑失败和子痫前期。结论COVID-19 感染与 RSD Soebandi Jember 医生的子痫前期发病率之间存在关系。关键词COVID-19、子痫前期、肾素-血管紧张素系统（RAS）、SARS-CoV-2 Abstrak Tujuan：在Soebandi Jember的RSD医生那里收集关于COVID-19基因对先兆子痫的影响的信息。方法：通过简单随机抽样的方式，对该地区进行研究。该项目收集了从 2020 年 5 月至 2021 年 9 月期间在苏班迪金巴拉省的 118 名学生的数据，并利用卡氏方差统计和逻辑回归统计进行分析。目的统计分析表明，在苏班迪金巴拉姆乡村发展中心，COVID-19、usia 和肥胖症的相关数据均有所减少。COVID-19变量是一个与子痫前期相关的变量，其OR值为4,045（95% CI为1,595 - 10,259）。这表明 COVID-19 基因对 RAS 的下调作用有助于重塑螺旋动脉和子痫前期：在Soebandi Jember博士的RSD研究中，发现了COVID-19的作用。关键词： COVID-19、疱疹、肾素-血管紧张素系统（RAS）、SARS-CoV-2

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来源期刊

Indonesian Journal of Obstetrics and Gynecology Medicine-Pathology and Forensic Medicine

CiteScore

0.10

自引率

0.00%

发文量

审稿时长

24 weeks