Nitric oxide therapy in COVID-19 patients with acute respiratory distress in intensive care unit

Anatolian Current Medical Journal Pub Date : 2023-10-27 DOI:10.38053/acmj.1317124

F. Seğmen, Duygu KAYAR ÇALILI, Güray Alp, Demet Bölükbaşı, Hülya DENİZ MISIR, E. Uysal, Nalan Demir, Deniz Erdem

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Abstract

Aims: The administration of inhaled nitric oxide (iNO) is a promising and new approach to treat viral load while increasing oxygenation directly. This research aimed to elucidate the clinical and laboratory response to the treatment of the patients diagnosed with Coronavirus disease-19 (COVID-19) in the intensive care unit (ICU) and followed up due to respiratory failure and given iNO. Methods: A total of 46 individuals who were diagnosed with COVID-19 and developed severe respiratory failure were followed up with or without intubation, had previously received standard care were evaluated within the study’s scope. iNO initiation time in the ICU, whether the patients were intubated, clinical and laboratory parameters before and after iNO treatment were obtained from hospital records. Results: A statistically significant difference has been achieved in arterial partial pressure of oxygen (PaO2), peripheral oxygen saturation (SpO2), and the ratio of arterial partial pressure of oxygen to fraction of inspired oxygen (PaO2/FiO2) ratios before and after iNO (p

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一氧化氮疗法在 COVID-19 重症监护室急性呼吸窘迫患者中的应用

目的：吸入一氧化氮（iNO）是治疗病毒载量的一种很有前景的新方法，同时可直接增加氧合作用。本研究旨在阐明重症监护室（ICU）中确诊为冠状病毒病-19（COVID-19）并因呼吸衰竭接受一氧化氮治疗的患者的临床和实验室反应。治疗方法从医院记录中获取患者在重症监护室开始使用 iNO 的时间、是否插管以及 iNO 治疗前后的临床和实验室指标。研究结果在 iNO 治疗前后，动脉血氧分压（PaO2）、外周血氧饱和度（SpO2）以及动脉血氧分压与吸入氧分压之比（PaO2/FiO2）在统计学上有明显差异（P＜0.05）。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Anatolian Current Medical Journal

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