MORPHOLOGICAL ASPECTS OF DEVELOPMENT OF MALIGNANT TUMORS UNDER THE CONDITIONS OF COMORBID PATHOLOGY AND MITOCHONDRIAL THERAPY

Cardiometry Pub Date : 2023-11-01 DOI:10.18137/cardiometry.2023.29.conf.14

O. I. Kit, A. Shikhlyarova, E. Frantsiyants, I. Kaplieva, I. Neskubina, G. V. Zhukova, V. A. Bandovkina, E. Surikova, L. K. Trepitaki

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Abstract

Morphological studies represent the most important part of evidence-based medicine, and in oncology they are an essential attribute in the diagnostics of malignant neoplasms. In experimental oncology, current models of the tumor growth are developed to be as close as possible to the actual biological life conditions. There is a need to study the pathogenesis of tumors in various variants of their orthotopic growth, the formation of bi-model systems with a combination of the malignant growth and comorbid conditions (chronic neurogenic pain, diabetes mellitus, hypothyroidism, obesity), the use of subcellular substrates for the induction of carcinogenesis and biotherapy. Among the important methods for studying the pathogenesis of tumors, morphology is on a par with advanced molecular genetic and biochemical methods, as well as radioimmunoassay techniques.Morphological studies represent the most important part of evidence-based medicine, and in oncology they are an essential attribute in the diagnostics of malignant neoplasms. In experimental oncology, current models of the tumor growth are developed to be as close as possible to the actual biological life conditions. There is a need to study the pathogenesis of tumors in various variants of their orthotopic growth, the formation of bi-model systems with a combination of the malignant growth and comorbid conditions (chronic neurogenic pain, diabetes mellitus, hypothyroidism, obesity), the use of subcellular substrates for the induction of carcinogenesis and biotherapy. Among the important methods for studying the pathogenesis of tumors, morphology is on a par with advanced molecular genetic and biochemical methods, as well as radioimmunoassay techniques.

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在合并病理学和线粒体疗法条件下恶性肿瘤发展的形态学方面

形态学研究是循证医学最重要的组成部分，而在肿瘤学中，形态学研究是诊断恶性肿瘤的基本要素。在肿瘤学实验中，目前建立的肿瘤生长模型尽可能接近实际生物生活条件。有必要研究肿瘤在各种变异的正位生长中的发病机理，研究恶性肿瘤生长与合并症（慢性神经源性疼痛、糖尿病、甲状腺机能减退、肥胖）相结合的双模型系统的形成，研究亚细胞底物在诱导癌变和生物治疗中的应用。在研究肿瘤发病机理的重要方法中，形态学与先进的分子遗传学和生物化学方法以及放射免疫分析技术并驾齐驱。形态学研究是循证医学最重要的组成部分，在肿瘤学中，形态学研究是恶性肿瘤诊断的基本属性。在肿瘤学实验中，目前建立的肿瘤生长模型尽可能接近实际生物生活条件。有必要研究肿瘤在各种变异的正位生长中的发病机理，研究恶性肿瘤生长与合并症（慢性神经源性疼痛、糖尿病、甲状腺机能减退、肥胖）相结合的双模型系统的形成，研究亚细胞底物在诱导癌变和生物治疗中的应用。在研究肿瘤发病机制的重要方法中，形态学与先进的分子遗传学和生物化学方法以及放射免疫分析技术并驾齐驱。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Cardiometry MEDICAL LABORATORY TECHNOLOGY-

自引率

0.00%

发文量

审稿时长

6 weeks

期刊介绍： Cardiometry is an open access biannual electronic journal founded in 2012. It refers to medicine, particularly to cardiology, as well as oncocardiology and allied science of biophysics and medical equipment engineering. We publish mainly high quality original articles, reports, case reports, reviews and lectures in the field of the theory of cardiovascular system functioning, principles of cardiometry, its diagnostic methods, cardiovascular system therapy from the aspect of cardiometry, system and particular approaches to maintaining health, engineering peculiarities in cardiometry developing. The interdisciplinary areas of the journal are: hemodynamics, biophysics, biochemistry, metrology. The target audience of our Journal covers healthcare providers including cardiologists and general practitioners, bioengineers, biophysics, medical equipment, especially cardiology diagnostics device, developers, educators, nurses, healthcare decision-makers, people with cardiovascular diseases, cardiology and engineering universities and schools, state and private clinics. Cardiometry is aimed to provide a wide forum for exchange of information and public discussion on above scientific issues for the mentioned experts.