Controlled release of dexamethasone from fibrin sealant for intratympanic administration in inner ear therapy

IF 1.4 Q2 OTORHINOLARYNGOLOGY

Journal of Otology Pub Date : 2024-01-01 DOI:10.1016/j.joto.2023.11.002

Jing Zou

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引用次数: 0

Abstract

The aim of the present work was to show the sustainability of fibrin sealant in releasing dexamethasone and adjust the protocol for clinical application of the novel method in the treatment of Meniere's disease (MD) and sudden sensorineural hearing loss (SSHL). Gelation occurred shortly after mixing dexamethasone-containing fibrinogen with thrombin. Dexamethasone was constantly released for at least 16 d at a stable level after 7 d in protocol 1 (low-dose), while it was robustly released within 4 d and slowed afterward until 10 d in protocol 2 (high-dose). There were significant differences among the time points in Protocol 2 (p < 0.01, ANOVA), and the exponential model with the formula y = 15.299 * e^−0.483 *^t fits the association. The estimated concentration of dexamethasone released on 7 d in protocol 2 was slightly lower than that observed in protocol 1. The fibrin sealant is capable of constantly releasing dexamethasone with adjustable dynamics. Targeted and minimally invasive administration of the material can be achieved in the clinic by sequential injections of the fluids using a soft-tipped catheter.

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从纤维蛋白密封剂中控制释放地塞米松，用于内耳治疗中的鼓室内给药

本研究的目的是证明纤维蛋白密封剂在释放地塞米松方面的可持续性，并调整新方法的临床应用方案，以治疗美尼尔氏病（MD）和突发性感音神经性听力损失（SSHL）。在将含地塞米松的纤维蛋白原与凝血酶混合后不久就出现了凝胶化。在方案 1（低剂量）中，地塞米松在 7 天后以稳定的水平持续释放至少 16 天，而在方案 2（高剂量）中，地塞米松在 4 天内大量释放，之后释放速度减慢，直到 10 天。在方案 2 中，各时间点之间存在显着差异（p < 0.01，方差分析），且 y = 15.299 * e-0.483 *t 的指数模型符合相关关系。方案 2 中第 7 d 释放的地塞米松估计浓度略低于方案 1 中观察到的浓度。纤维蛋白密封剂能够以可调节的动态方式持续释放地塞米松。在临床上，可通过使用软头导管连续注射液体来实现有针对性的微创给药。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Otology Medicine-Otorhinolaryngology

CiteScore

2.70

自引率

0.00%

发文量

461

审稿时长

18 days

期刊介绍： Journal of Otology is an open access, peer-reviewed journal that publishes research findings from disciplines related to both clinical and basic science aspects of auditory and vestibular system and diseases of the ear. This journal welcomes submissions describing original experimental research that may improve our understanding of the mechanisms underlying problems of basic or clinical significance and treatment of patients with disorders of the auditory and vestibular systems. In addition to original papers the journal also offers invited review articles on current topics written by leading experts in the field. The journal is of primary importance for all scientists and practitioners interested in audiology, otology and neurotology, auditory neurosciences and related disciplines. Journal of Otology welcomes contributions from scholars in all countries and regions across the world.