Calculating the Delta Entropy of Differentiation Module in Different Paediatric Sepsis via Analysis of Gene Network

Pub Date : 2023-11-02 DOI:10.31901/24566330.2024/24.01.823
Dan Yu
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Abstract

Paediatric sepsis refers to the body reaction disorder caused by the infection of blood by pathogens. In this study, the researchers aimed to differentiate the 5 types of paediatric sepsis by integrating the mRNA data and PINs analysis. Twenty-three SIRS, 24 uncomplicated sepsis, 21 severe sepsis, 33 septic shock and 28 sepsis deaths were enrolled. The potential genes related to paediatric sepsis were explored. The researchers found that the nodes of SIRS modules were 8, 7 and 4 with corresponding edges of 28, 21 and 6. The nodes of uncomplicated sepsis were 6, 3 and 5, with corresponding edges of 15, 3 and 10. The nodes of severe sepsis module and corresponding edges respectively were 3 and 3. One differentiation module of sepsis death contained 4 nodes and 6 edges. In conclusion, the genes that participate in the ribosome and cell cycle pathways probably play important roles in the development of paediatric sepsis.
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通过基因网络分析计算不同儿科败血症分化模块的德尔塔熵
小儿败血症是指病原体感染血液后引起的机体反应失调。在这项研究中,研究人员旨在通过整合 mRNA 数据和 PINs 分析来区分 5 种类型的儿科败血症。研究人员对 23 例 SIRS、24 例无并发症败血症、21 例严重败血症、33 例脓毒性休克和 28 例败血症死亡病例进行了研究。研究人员探索了与儿科败血症相关的潜在基因。研究人员发现,SIRS 模块的节点分别为 8、7 和 4,相应的边分别为 28、21 和 6。未并发败血症的节点分别为 6、3 和 5,对应的边分别为 15、3 和 10。严重败血症模块的节点和相应的边分别为 3 和 3。败血症死亡的一个分化模块包含 4 个节点和 6 条边。总之,参与核糖体和细胞周期途径的基因可能在小儿败血症的发病过程中起着重要作用。
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