Calotropis procera leaf extract against paracetamol induced hepatotoxicity in Rats by regulating JNK/ASK-1 Signaling Pathway

IF 0.2 Q4 BIOTECHNOLOGY & APPLIED MICROBIOLOGY
K. K. Agrawal, Y. Murti
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引用次数: 0

Abstract

The goal of the study was to assess the hepatoprotective efficacy of young Calotropis procera leaves. The young leaves of Calotropis procera were extracted by cold maceration with ultra-sonication using chloroform, ethyl acetate and distilled water. Male Wistar rats were used for hepatoprotective evaluation and the body weight, liver weight, serum biomarkers and anti-oxidant markers were measured during study. The extract/fractions significantly (P<0.05) increased the absolute and relative weight of the liver of rats at the dose of 200 mg/kg. It also suppressed the serum biomarkers (P<0.05) in the aforementioned doses. Oral administration of extract/fractions significantly increase the oxidative marker and decreased the progression of paracetamol induced hepatotoxicity. The result of the study suggested that Calotropis procera leaf extract/fractions can reduce hepatotoxicity caused by paracetamol.
石菖蒲叶提取物通过调节 JNK/ASK-1 信号通路对抗扑热息痛诱导的大鼠肝毒性
这项研究的目的是评估草苁蓉嫩叶的保肝功效。研究人员使用氯仿、乙酸乙酯和蒸馏水,通过冷浸渍和超音波法萃取了草决明嫩叶。研究过程中对雄性 Wistar 大鼠的体重、肝脏重量、血清生物标志物和抗氧化标志物进行了测量。在剂量为 200 毫克/千克时,提取物/馏分能明显增加大鼠肝脏的绝对和相对重量(P<0.05)。在上述剂量下,它还抑制了血清生物标志物(P<0.05)。口服提取物/馏分可明显增加氧化标志物,并降低扑热息痛诱导的肝毒性进展。研究结果表明,石菖蒲叶提取物/萃取物可以减轻扑热息痛引起的肝毒性。
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来源期刊
Research Journal of Biotechnology
Research Journal of Biotechnology BIOTECHNOLOGY & APPLIED MICROBIOLOGY-
CiteScore
0.60
自引率
0.00%
发文量
192
期刊介绍: We invite you to contribute Research Papers / Short Communications / Review Papers: -In any field of Biotechnology, Biochemistry, Microbiology and Industrial Microbiology, Soil Technology, Agriculture Biotechnology. -in any field related to Food Biotechnology, Nutrition Biotechnology, Genetic Engineering and Commercial Biotechnology. -in any field of Biotechnology related to Drugs and Pharmaceutical products for human beings, animals and plants. -in any field related to Environmental Biotechnolgy, Waste Treatment of Liquids, Soilds and Gases; Sustainability. -in inter-realted field of Chemical Sciences, Biological Sciences, Environmental Sciences and Life Sciences. -in any field related to Biotechnological Engineering, Industrial Biotechnology and Instrumentation. -in any field related to Nano-technology. -in any field related to Plant Biotechnology.
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