Pentadentate and Hexadentate Pyridinophane Ligands Support Reversible Cu(II)/Cu(I) Redox Couples

IF 3.1 4区化学 Q2 CHEMISTRY, INORGANIC & NUCLEAR

Inorganics Pub Date : 2023-11-20 DOI:10.3390/inorganics11110446

Glenn Blade, Andrew J. Wessel, Karna Terpstra, Liviu M. Mirica

引用次数: 0

Abstract

Two new ligands were synthesized with the goal of copper stabilization, N,N′-(2-methylpyridine)-2,11-diaza[3,3](2,6)pyridinophane (PicN4) and N-(methyl),N′-(2-methylpyridine)-2,11-diaza[3,3](2,6)pyridinophane (PicMeN4), by selective functionalization of HN4 and TsHN4. These two ligands, when reacted with various copper salts, generated both Cu(II) and Cu(I) complexes. These ligands and Cu complexes were characterized by various methods, such as NMR, UV-Vis, MS, and EA. Each compound was also examined electrochemically, and each revealed reversible Cu(II)/Cu(I) redox couples. Additionally, stability constants were determined via spectrophotometric titrations, and radiolabeling and cytotoxicity experiments were performed to assess the chelators relevance to their potential use in vivo as 64Cu PET imaging agents.

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五齿和六齿吡啶玢配体支持可逆的铜（II）/铜（I）氧化还原偶联物

为了稳定铜，我们合成了两种新配体，即 N,N′-(2-甲基吡啶)-2,11-二氮杂[3,3](2,6)吡啶烷 (PicN4) 和 N-(甲基)、通过选择性地官能化 HN4 和 TsHN4，得到 N′-(2-甲基吡啶)-2,11-二氮杂[3,3](2,6)吡啶磷烷 (PicMeN4)。这两种配体与各种铜盐反应后，生成了 Cu(II) 和 Cu(I) 复合物。这些配体和铜络合物通过核磁共振、紫外可见光、质谱和电子显微镜等多种方法进行了表征。还对每种化合物进行了电化学研究，发现每种化合物都具有可逆的 Cu(II)/Cu(I) 氧化还原偶联。此外，还通过分光光度滴定法确定了稳定性常数，并进行了放射性标记和细胞毒性实验，以评估螯合剂作为 64Cu PET 成像剂在体内的潜在用途。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Inorganics Chemistry-Inorganic Chemistry

CiteScore

2.80

自引率

10.30%

发文量

193

审稿时长

6 weeks

期刊介绍： Inorganics is an open access journal that covers all aspects of inorganic chemistry research. Topics include but are not limited to: synthesis and characterization of inorganic compounds, complexes and materials structure and bonding in inorganic molecular and solid state compounds spectroscopic, magnetic, physical and chemical properties of inorganic compounds chemical reactivity, physical properties and applications of inorganic compounds and materials mechanisms of inorganic reactions organometallic compounds inorganic cluster chemistry heterogenous and homogeneous catalytic reactions promoted by inorganic compounds thermodynamics and kinetics of significant new and known inorganic compounds supramolecular systems and coordination polymers bio-inorganic chemistry and applications of inorganic compounds in biological systems and medicine environmental and sustainable energy applications of inorganic compounds and materials MD