Diagnostic Value of Apparent Diffusion Coefficient Statistics in Differentiating the Glioblastoma Tumors with an Oligodendroglioma and Glioblastomas Without Such Moiety

IF 0.4 Q4 ONCOLOGY

International Journal of Cancer Management Pub Date : 2023-11-20 DOI:10.5812/ijcm-119301

Mersad Mehrnahad, Morteza Sanei Taheri, Farnaz Kimia, H. Saligheh Rad, Robabeh Ghodssi GhassemAbadi

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引用次数: 0

Abstract

Background: Differentiating types of brain tumors using magnetic resonance imaging (MRI) as a non-invasive element is essential. Objectives: The study aimed at evaluating the difference in the first-order histogram (FOH) features obtained from apparent diffusion coefficients (ADCs) between glioblastoma (GBM) tumors with or without oligodendroglial (ODG) components. Methods: MRIs were taken before surgical resection of the brain tumors. The brain lesions were analyzed and ADC maps were plotted to calculate FOH. Brain lesions were surgically removed, diagnosed using pathological methods, and categorized as GBM with an ODG (GBM-ODG) or without ODG. A comparison of ADC values was performed between GBM-ODG and GBM. Receiver-operator characteristic (ROC) curves were used to determine the cut-off sensitivity and specificity values. Results: In the GBM group, 26 patients were included; 20 cases were male and 6 were female; the mean ± SD of age was 54.1 ± 1.2 and 55.2 ± 1.6 years, respectively. In the GBM-ODG group, 31 patients were included; 22 cases were male and 9 cases were female; the mean ± SD of 52.1 ± 0.8 and 55.3 ± 1.5 years, respectively. The results of peritumoral edema had several significant FOHs. In the MRIs of tumor and T1W groups, the third moment and minimum-ADC had significant results, respectively. Cut-off values of the FOHs were statistically significant outcomes in the peritumoral edema region when compared between GBM-ODG and GBM categories: Median > 1.3516, normal mean > 0.6671, third moment ≤ -0.0001, 25 percentile > 0.5929, 75 percentile > 0.7336, and 95 percentile > 0.8542. The highest sensitivity and specificity values for these FOHs were higher than 80% and sometimes near 99.9%. Conclusions: The results showed that ADC values from peritumoral edema regions differ between these two types of tumors. Then, an MRI from the edematous areas is suggested when evaluating the patient's status and deciding to make interventions.

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表观弥散系数统计在区分胶质母细胞瘤中的寡树突胶质细胞瘤和不含寡树突胶质细胞瘤的胶质母细胞瘤中的诊断价值

背景：利用磁共振成像（MRI）这一无创元素区分脑肿瘤类型至关重要。研究目的本研究旨在评估有无少突胶质细胞（ODG）成分的胶质母细胞瘤（GBM）肿瘤之间从表观扩散系数（ADC）获得的一阶直方图（FOH）特征的差异。方法脑肿瘤手术切除前进行核磁共振成像。分析脑部病变，绘制 ADC 图以计算 FOH。脑损伤经手术切除后，采用病理方法进行诊断，并分为有 ODG 的 GBM（GBM-ODG）和无 ODG 的 GBM。对 GBM-ODG 和 GBM 的 ADC 值进行比较。使用接收器-操作者特征（ROC）曲线确定敏感性和特异性的临界值。结果显示GBM 组共纳入 26 例患者，其中男性 20 例，女性 6 例；平均年龄（±SD）分别为 54.1±1.2 岁和 55.2±1.6 岁。GBM-ODG组共31例，男性22例，女性9例；平均年龄（±SD）分别为（52.1±0.8）岁和（55.3±1.5）岁。瘤周水肿的结果有几个明显的FOH。在肿瘤组和T1W组的磁共振成像中，第三矩和最小ADC分别有显著结果。与 GBM-ODG 和 GBM 类别相比，瘤周水肿区域的 FOH 临界值具有统计学意义：中位数>1.3516，正常平均值>0.6671，第三矩≤-0.0001，25百分位数>0.5929，75百分位数>0.7336，95百分位数>0.8542。这些 FOHs 的最高灵敏度和特异性值均高于 80%，有时接近 99.9%。结论结果显示，这两种类型肿瘤的瘤周水肿区的 ADC 值不同。因此，在评估患者状况并决定是否进行干预时，建议对水肿区域进行 MRI 检查。

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来源期刊

International Journal of Cancer Management ONCOLOGY-

CiteScore

1.10

自引率

0.00%

发文量

期刊介绍： International Journal of Cancer Management (IJCM) publishes peer-reviewed original studies and reviews on cancer etiology, epidemiology and risk factors, novel approach to cancer management including prevention, diagnosis, surgery, radiotherapy, medical oncology, and issues regarding cancer survivorship and palliative care. The scope spans the spectrum of cancer research from the laboratory to the clinic, with special emphasis on translational cancer research that bridge the laboratory and clinic. We also consider original case reports that expand clinical cancer knowledge and convey important best practice messages.