Weight regain after total meal replacement very low‐calorie diet program with and with‐out anti‐obesity medications

Obesity Science & Practice Pub Date : 2023-11-20 DOI:10.1002/osp4.722

Lizeth Cifuentes, Francesca Galbiati, Hussain Mahmud, David Rometo

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Abstract

Very low‐calorie diets (VLCDs) employing total meal replacement (TMR) offer substantial short‐term weight loss. Concurrently, anti‐obesity medications (AOMs) have shown promise as adjunctive treatments when combined with VLCDs.This study aimed to investigate the impact of adjuvant AOMs on weight loss and weight regain within a comprehensive lifestyle program.This is a retrospective study of patients with obesity enrolled in VLCD/TMR programs, specifically the OPTIFAST program.Data from 206 patients (68% women, mean age 52.39 ± 13.05 years, BMI 41.71 ± 7.04 kg/m2) were analyzed. Of these, 139 received no AOM (AOM‐), while 67 received AOMs (AOM+). Total body weight loss percentages (TWL%) at 6 and 18 months were −17.87% ± 7.02 and −12.10% ± 11.56, respectively. There was no significant difference in 6‐month weight loss between the AOM groups. However, the AOM + group exhibited lower weight regain (3.29 kg ± 10.19 vs. 7.61 kg ± 11.96; p = 0.006) and weight regain percentage (WR%) (31.5% ± 68.7 vs. 52.16% ± 64.4; p = 0.04) compared with the AOM‐ group.The findings highlighted the potential of AOMs and VLCD/TMR as effective strategies for long‐term weight management in individuals with obesity.

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使用或不使用抗肥胖药物的全餐替代超低卡路里饮食计划后体重反弹

采用全餐替代（TMR）的超低卡路里饮食（VLCD）可在短期内大幅减轻体重。本研究旨在调查在一项综合生活方式计划中，辅助性抗肥胖药物（AOMs）对体重减轻和体重反弹的影响。本研究是一项回顾性研究，研究对象是参加 VLCD/TMR 计划（特别是 OPTIFAST 计划）的肥胖症患者。其中，139 人未接受 AOM（AOM-），67 人接受了 AOM（AOM+）。6个月和18个月的总体重减轻率（TWL%）分别为-17.87% ± 7.02和-12.10% ± 11.56。AOM组与AOM+组在6个月的体重减轻率上没有明显差异。然而，与AOM-组相比，AOM +组的体重反弹率（3.29 kg ± 10.19 vs. 7.61 kg ± 11.96; p = 0.006）和体重反弹百分比（WR%）（31.5% ± 68.7 vs. 52.16% ± 64.4; p = 0.04）较低。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Obesity Science & Practice

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