Cerebrospinal Fluid Flow Parameters in Normal Subjects above 40 Years of Age

IF 0.9 Q4 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING

Indian Journal of Radiology and Imaging Pub Date : 2023-11-20 DOI:10.1055/s-0043-1776413

S. Rohilla, Pradeep Kumar, I. Singh

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Abstract

Abstract Background Cerebrospinal fluid (CSF) flow is altered in many conditions like normal pressure hydrocephalus (NPH), aqueduct stenosis, or Chiari malformation. It is very important to know the normal CSF flow parameters for properly diagnosing these conditions. No data on CSF flow parameters of the Indian population are available. Hence, this study was undertaken to generate normative CSF flow parameters in the Indian population. Aim Our aim was to estimate normal CSF flow parameters across the cerebral aqueduct in Indian subjects over 40 years of age. Settings and Design This observational study was done in the tertiary care institute on subjects undergoing magnetic resonance imaging (MRI) for indications like headache and having normal MRI. Methods Phase-contrast quantitative flow sequence was done in 100 subjects perpendicular to the cerebral aqueduct on 3.0T MRI (Discovery 750w with GEM suit, GE, Milwaukee, WI, United States) using a dedicated 32-channel head coil with 10 cm/s velocity encoding. The region of interest was kept at the cerebral aqueduct in cross-section. The inbuilt software calculated flow-time and velocity-time graphs and calculated peak systolic velocity (PSV), peak diastolic velocity (PDV), systolic flow (SF), and diastolic flow (DF). Stroke volume (SV) was calculated by averaging systolic and DFs. p -Value < 0.05 was considered significant. Results Mean age was 53.72 ± 10.53 (40–78) years with 41 males and 59 females. PSV, PDV, SF, DF, and SV all showed a significant linear correlation with age with p -values of 0.001, 0.004, 0.009, <0.001, and <0.001, respectively. Only PDV ( p = 0.035) and DF ( p = 0.045) varied significantly with sex, values being higher in males. Conclusion All five CSF flow parameters studied vary positively with age, and this variation is linear. Normal decadal median values calculated for these parameters can act as baseline values for the local population and help in defining conditions like NPH.

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40 岁以上正常人的脑脊液流量参数

摘要背景正常压力脑积水（NPH）、导水管狭窄或奇异畸形等许多疾病都会导致脑脊液（CSF）流改变。了解正常的 CSF 流参数对正确诊断这些疾病非常重要。目前还没有关于印度人群脑脊液流动参数的数据。因此，本研究旨在生成印度人群的正常 CSF 流参数。目的我们的目的是估算 40 岁以上印度受试者跨脑导水管的正常 CSF 流量参数。设置和设计这项观察性研究在三级医疗机构进行，对象是因头痛等原因接受磁共振成像（MRI）检查且磁共振成像正常的受试者。方法在 3.0T 磁共振成像（带 GEM 套装的 Discovery 750w，GE 公司，密尔沃基，威斯康星州，美国）上，使用专用的 32 通道头部线圈和 10 厘米/秒速度编码，对 100 名受试者进行了垂直于大脑导水管的相位对比定量血流序列检查。感兴趣区保持在大脑导水管横截面上。内置软件计算流量-时间和速度-时间图，并计算收缩期峰值速度（PSV）、舒张期峰值速度（PDV）、收缩期流量（SF）和舒张期流量（DF）。通过计算收缩压和舒张压的平均值得出每搏量（SV）。结果平均年龄为 53.72 ± 10.53（40-78）岁，其中男性 41 人，女性 59 人。PSV、PDV、SF、DF 和 SV 均与年龄呈显著线性相关，p 值分别为 0.001、0.004、0.009、<0.001 和 <0.001。只有 PDV（p = 0.035）和 DF（p = 0.045）与性别有显著差异，男性的数值更高。结论所研究的五项脑脊液流量参数均随年龄呈正向变化，且呈线性变化。计算出的这些参数的十年正常中位值可作为当地人口的基线值，并有助于确定 NPH 等疾病。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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