Influence of Etomersol Fumarate on Cognitive Functions of Rats During Mercury Acetate Poisoning

Abstract

Research into the consequences of human exposure to heavy metals acquires particular significance in the context of life and working age prolongation. Such consequences can be manifested either in the form of selective damage to any organ, organ system or function, or in the form of a general violation of the functions of a number of systems and organs and the organism as a whole, in the form of “disintegration of functions”. In this work, we set out to study the neuroprotective effect of etomerzol fumarate after a subchronic low-dose administration of mercury acetate to Wistar rats. After an intragastric administration of an aqueous solution of mercury acetate at a dose of 4 mg/kg for 30 days, a violation of the learning process was identified in an active avoidance by swimming test. The use of the test substance at a dose of 12.5 mg/kg for 14 days had a positive effect on the long-term memory of animals, contributing to the preservation and reproduction of mercury information received.