Network Pharmacology Study on the Neurotoxic Mechanism of Acorus tatarinowii

Abstract

Acorus tatarinowii was a traditional Chinese medicine used to treat neurological diseases such as epilepsy with significant effects. When the oral dosage is too large, it has potential neurotoxic effects. However, the toxicity mechanism is still unclear. In this study network pharmacology methods were used to explore the mechanism of neurotoxicity of Acorus tatarinowii. The results showed that 5 toxic components of Acorus tatarinowii were identified, involving 73 neurotoxic targets. Among them, AKT1, CASP3, PTGS2, ESR1, EGFR, HIF1A, GSK3B, MMP9, SRC, and CCND1 may be key targets for Acorus tatarinowii to exert neurotoxic effects; KEGG pathway analysis found that the neurotoxicity caused by Acorus tatarinowii may be mainly related to Pathways in cancer, Endocrine resistance, and Chemical carcinogenesis-receptor activation. It was found that Acorus tatarinowii may exert neurotoxic effects through multiple components and targets.