Protective effects of Mosla Chinensis Maxim against Lung Injury

Abstract

Lung fibrosis is a common form of interstitial lung disease. Traditional Chinese medicinal plants have the ability to suppress lung inflammation, but there are relatively few studies on the relationship between Mosla Chinensis Maxim and lung injury. The purpose of this study was to investigate whether Mosla Chinensis Maxim extract (MCME) can alleviate lung injury. This study utilized lung epithelial cells, A549, treated MCME (0.25mg/mL), and analyzed the wound-healing ability, inflammatory cytokines, and cell-cell adheren junctions (E-cadherin). Bleomycin was used to induced lung fibrosis in an animal model, which were then treated with MCME. The results showed that MCME improved cellular repair capacity by 30% compared to the mock group, inhibited IL-8 by approximately 60%, and increased the E-cadherin expression compared to the lipopolysaccharide group. In an animal model, administration of MCME (50 mg/kg) for 14 days alleviated the bleomycin-induced pathological changes in the lungs and fibrosis. This study demonstrated that MCME improved lung injury.