DETERMINATION OF MICRONUTRIENTS IN DIABETIC WOMEN: A SERUM ANALYSIS OF SEVEN ELEMENTS

Periódico Tchê Química Pub Date : 2023-11-26 DOI:10.52571/ptq.v20.n45.2023.05_khalaf_pgs_38_48.pdf

Zainab Ali Khalaf, Yusra Sabri Abdul-Saheb, S. Najim

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Abstract

Background: The human body needs minerals and micronutrients. It is important to estimate the micronutrients (Fe+2, Mg+2, Mn+2, Zn+2, Cu+2, K+, Na+) in the serum of female patients with diabetes mellitus (T2DM) as needed for insulin and glucose metabolism, especially zinc, manganese, and magnesium, which activate insulin receptor sites. Aim: Estimate the micronutrient concentrations by (µg/mL) and determine their effects on insulin resistance and diabetes mellitus. Methods: The study was conducted at Maysan Province Endocrinology and Diabetes Center from January to April 2023. It included 120 women aged (20 – 65) years separated into two groups. The control group included 40 healthy women, and the patient group included 80 women with diabetic mellitus (T2DM). The IBM SPSS Statistics and the t-test were used to compare the two groups. Results: The results showed a statistically significant difference at the level (P?0.05) for the average concentration of Magnesium, Manganese, Zinc, Copper, Potassium, and Sodium, while Iron concentration was a non-significant decrease at (P?0.05) in the patients with (T2DM) compared with the control group. The concentration of micronutrients in diabetes mellitus and healthy groups was Na+ > Cu+2 > Zn+2 > Mn+2 > Fe+2 > K+ > Mg+2 and Na+ > Cu+2 > K+ > Mg+2 > Fe+2 > Zn+2 > Mn+2 respectively. In the T2DM group, the trace element with the highest observed concentration was the Sodium ion, while Manganese (Mn+2) had the lowest concentration. Conversely, in the control group, Sodium (Na+) showed the highest concentration and Magnesium (Mg+2) the lowest. Discussion: Sodium had the greatest micronutrient content in both the control and T2DM groups. Micronutrient differences may affect insulin resistance and diabetes. Conclusions: The variation in the micronutrient concentration was statistically significant between the diabetes mellitus and control groups, except for Iron, demonstrating the complex relationship between micronutrient levels and metabolic disorders

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糖尿病妇女微量营养素的测定：七种元素的血清分析

背景：人体需要矿物质和微量元素。胰岛素和葡萄糖代谢需要微量营养素（Fe+2、Mg+2、Mn+2、Zn+2、Cu+2、K+、Na+），尤其是能激活胰岛素受体位点的锌、锰和镁，因此估算女性糖尿病患者（T2DM）血清中的微量营养素（Fe+2、Mg+2、Mn+2、Zn+2、Cu+2、K+、Na+）非常重要。目的：估算微量营养素的浓度（微克/毫升），并确定其对胰岛素抵抗和糖尿病的影响。研究方法研究于 2023 年 1 月至 4 月在梅桑省内分泌与糖尿病中心进行。研究对象包括 120 名年龄在（20 - 65）岁之间的妇女，分为两组。对照组包括 40 名健康妇女，患者组包括 80 名糖尿病（T2DM）妇女。采用 IBM SPSS 统计和 t 检验对两组进行比较。结果显示结果表明，与对照组相比，T2DM 患者体内镁、锰、锌、铜、钾和钠的平均浓度差异有统计学意义（P?0.05），而铁的浓度下降不明显（P?0.05）。糖尿病组和健康组的微量营养素浓度分别为 Na+ > Cu+2 > Zn+2 > Mn+2 > Fe+2 > K+ > Mg+2 和 Na+ > Cu+2 > K+ > Mg+2 > Fe+2 > Zn+2 > Mn+2 。在 T2DM 组中，观察到浓度最高的微量元素是钠离子，而锰（Mn+2）的浓度最低。相反，在对照组中，钠离子（Na+）的浓度最高，镁离子（Mg+2）的浓度最低。讨论在对照组和 T2DM 组中，钠的微量营养素含量最高。微量营养素的差异可能会影响胰岛素抵抗和糖尿病。结论除铁外，糖尿病组和对照组之间微量营养素浓度的差异在统计学上有显著意义，这表明微量营养素水平与代谢紊乱之间存在复杂的关系。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Periódico Tchê Química

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