Comparison of Cryotherapy and Topical Salicylic Acid in Common Warts: A Systematic Review and Meta-Analysis

IF 3.7 4区医学 Q1 DERMATOLOGY

Dermatologic Therapy Pub Date : 2023-11-27 DOI:10.1155/2023/4283918

Dipika Chaudhary, Yan Sun, Xinghua Gao

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引用次数: 0

Abstract

Background. Common warts are most common complaint among children and adults caused by human papillomavirus (HPV). Cryotherapy and topical salicylic acid are common therapies. Objective. To compare the efficacy and safety of cryotherapy and topical salicylic acid in common warts. Methods. Randomized controlled trials (RCTs) comparing cryotherapy and topical salicylic acid treatment in patients with common warts were searched by using PubMed, Embase, Google Scholar, and Cochrane Database of Systematic Reviews up to Oct 20, 2021. The keywords were “common warts/verruca,” “cryotherapy,” and “salicylic acid.” The language was restrained to English. No age or gender limitation was conducted. The outcomes were complete remission of all warts at different observation times, recurrence rates, and side effects. Study-specific effect sizes were pooled by using the fixed-effects model and the Mantel–Haenszel method. I2 was used to assess heterogeneity of studies. Results. Seven articles involving 976 patients randomized into the cryotherapy group or salicylic acid group were included. Of whom, 487 patients received cryotherapy, while 489 received salicylic acid treatment. With the fixed-effects model, the pool effect of complete clearance of warts at 12 weeks comparing cryotherapy and salicylic acid was not statistically significant (RR = 0.99 (0.84–1.17), I2 = 0%). Conclusion. Comparable efficacy of cryotherapy and topical salicylic acid was conducted in common wart treatment. More high-quality pieces of evidence with more samples are needed to confirm the results for further recommendations.

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冷冻疗法与外用水杨酸治疗寻常疣的比较：系统回顾与元分析

背景。寻常疣是由人类乳头瘤病毒（HPV）引起的儿童和成人最常见的疾病。冷冻疗法和外用水杨酸是常用疗法。目的比较冷冻疗法和外用水杨酸对寻常疣的疗效和安全性。方法。使用 PubMed、Embase、Google Scholar 和 Cochrane 系统综述数据库（截至 2021 年 10 月 20 日）检索了比较冷冻疗法和外用水杨酸治疗寻常疣患者的随机对照试验（RCT）。关键词为 "寻常疣/疣"、"冷冻疗法 "和 "水杨酸"。语言限于英语。没有年龄或性别限制。研究结果包括不同观察时间内所有疣体的完全缓解情况、复发率和副作用。采用固定效应模型和 Mantel-Haenszel 方法对特定研究的效应大小进行汇总。I2 用于评估研究的异质性。结果。共纳入 7 篇文章，涉及 976 名患者，随机分为冷冻治疗组或水杨酸组。其中，487 名患者接受了冷冻疗法，489 名患者接受了水杨酸治疗。在固定效应模型下，冷冻疗法与水杨酸疗法在12周时疣体完全清除的集合效应比较无统计学意义（RR = 0.99 (0.84-1.17), I2 = 0%）。结论冷冻疗法和外用水杨酸治疗寻常疣的疗效相当。需要更多高质量的证据和更多的样本来证实结果，以便进一步提出建议。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Dermatologic Therapy 医学-皮肤病学

CiteScore

7.00

自引率

8.30%

发文量

711

审稿时长

3 months

期刊介绍： Dermatologic Therapy has been created to fill an important void in the dermatologic literature: the lack of a readily available source of up-to-date information on the treatment of specific cutaneous diseases and the practical application of specific treatment modalities. Each issue of the journal consists of a series of scholarly review articles written by leaders in dermatology in which they describe, in very specific terms, how they treat particular cutaneous diseases and how they use specific therapeutic agents. The information contained in each issue is so practical and detailed that the reader should be able to directly apply various treatment approaches to daily clinical situations. Because of the specific and practical nature of this publication, Dermatologic Therapy not only serves as a readily available resource for the day-to-day treatment of patients, but also as an evolving therapeutic textbook for the treatment of dermatologic diseases.