Melphalan Tedavisi Alan Otolog Kök Hücre Transplantasyonu Olan Hastalarda Mukozitten Korunmada Oral Buz Uygulamasının Etkisi: Randomize Kontrollü Bir Çalışma

Abstract

Objective: To examine the effect of oral cryotherapy in the prevention of mucositis in patients with autologous stem cell transplantation receiving Melphelan therapy. Materials and Methods: The study was conducted in a prospective, randomized controlled study. Fifty patients who met the criteria for the study were recruited. Continuing to store the ice application in the intervention slots 5 minutes ago, continuing the treatment and spraying the next 15 minutes. continued throughout. Patients in the control devices received standard care. Results: It was found that the absence of oral mucositis in the intervention group was high at all times, the presence of mucositis in stage 2 was stable in both groups in all time periods, and the frequency of stage 3 mucositis was relatively higher in the control group from the 7th time period (p