Borderline hypernatraemia and mortality rates in South African infants: A single-centre observational study

IF 0.2 Q4 PEDIATRICS
N. Naka, MMed Paeds, F. Solomon, S. A. Madhi, PhD J M Pettifor, PhD Z Dangor, S. G. Lala
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引用次数: 0

Abstract

Background. In children, hypernatraemia occurs most commonly in infants (younger than 1 year). Although hypernatraemia is associated with high mortality and morbidity rates, it is variably defined in the paediatric literature as either serum sodium ≥150 mmol/L or serum sodium >145 mmol/L. In hospitalised adults, a serum sodium level >145 mmol/L but <150 mmol/L (called borderline hypernatraemia) has recently been identified as an independent risk factor for mortality. There are limited data about a potential association between borderline hypernatraemia and mortality in infants.  Objectives. To determine whether borderline hypernatraemia is associated with increased mortality in hospitalised infants.  Methods. We conducted a single-centre, retrospective observational study of 8 343 infants admitted to a tertiary-level academic hospital in Johannesburg, South Africa, of whom 254 had borderline hypernatraemia, 376 had hypernatraemia (serum sodium ≥150 mmol/L), and 7 713 did not have hypernatraemia. Mortality rates were reported as odds ratios (ORs) with 95% confidence intervals (CIs).  Results. In 254 infants with borderline hypernatraemia, 115 (45.3%) were neonates (≤28 days old) and 140 (55.1%) were male. In 139 infants >28 days old with borderline hypernatraemia, the mortality rate (n=9/139; 6.5%) was significantly higher than the mortality rate observed in infants without hypernatraemia (n=194/5 857; 3.3%) (OR 2.02; 95% CI 1.03 - 3.98).  Conclusion. Borderline hypernatraemia may be a risk factor associated with higher mortality in hospitalised infants. Prospective studies are required to determine whether borderline hypernatraemia contributes independently to mortality risk in hospitalised infants.
南非婴儿的边缘性高钠血症和死亡率:单中心观察研究
背景。在儿童中,高钠血症最常见于婴儿(1 岁以下)。虽然高钠血症与高死亡率和发病率有关,但儿科文献中对高钠血症的定义不尽相同,有的认为血清钠≥150 毫摩尔/升,有的认为血清钠>145 毫摩尔/升。在血清钠水平大于 145 毫摩尔/升但出生 28 天的成人住院患者中,边缘性高钠血症的死亡率(n=9/139;6.5%)明显高于无高钠血症婴儿的死亡率(n=194/5 857;3.3%)(OR 2.02;95% CI 1.03 - 3.98)。 结论边缘性高钠血症可能是导致住院婴儿死亡率升高的一个风险因素。需要进行前瞻性研究,以确定边缘性高钠血症是否会单独导致住院婴儿的死亡风险。
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来源期刊
CiteScore
0.60
自引率
0.00%
发文量
21
审稿时长
12 weeks
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