Cost-Effectiveness Analysis of Rabies Control Program, 2008–2017: A Systematic Review

Abstract

Rabies is still a public health problem. It is a zoonotic disease caused by a viral infection of the central nervous system. Several efforts have been taken, and one of them is mass vaccination for dogs. This systematic review aims to assess the cost-effectiveness of controlling rabies disease. Three online databases used as the source of this review are PubMed, ProQuest and CINAHL (EBSCO), published between 2008 and 2017. Fourteen articles reviewed based on the eligibility criteria were related to the intervention in preventing and controlling rabies. The articles consist of three randomised controlled trials and six nonrandomised controlled trials, including a pre-test-post-test-controlled design. Moreover, there is a one-time series article, which is an intervention for only one group of samples. Eight articles are directed at the intervention of lifestyles involving increased physical activity, diet and nutrition, with the main purpose to prevent the increase of metabolic syndrome status. Cost-effectiveness estimation is based on the mass vaccination programme for dogs, post-exposure prophylaxis (PEP) administration for humans and the combination of both. The model and variables in cost-effectiveness analysis are widely varied and associated with demography, socio-economics and programmes conducted in the study area.