Selectivity, synthesis, crystal structure and biological activity of the anion-coordination phenanthrolinium tartratogermanate

IF 0.5 Q4 CHEMISTRY, MULTIDISCIPLINARY
E. Afanasenko, I. Seifullina, E.V. Martsinko, V. Dyakonenko, S. Shishkina
{"title":"Selectivity, synthesis, crystal structure and biological activity of the anion-coordination phenanthrolinium tartratogermanate","authors":"E. Afanasenko, I. Seifullina, E.V. Martsinko, V. Dyakonenko, S. Shishkina","doi":"10.19261/cjm.2023.1121","DOIUrl":null,"url":null,"abstract":"Novel supramolecular cation-anionic coordination compound (HPhen)4[(μ-O){Ge2(OH) (μ-Tart)2}2]·9H2O was synthesised and characterised by the X-ray, elemental, IR- and Hirshfeld surface analysis. It was established that original synthesis method and ability of 1,10-phenanthroline to be protonated promotes the formation of [(μ-O){Ge2(OH)(μ-Tart)2}2]4- anion. In this anion, dimeric fragments are connected by a bridging oxygen atom, and the coordination polyhedra around the germanium atoms adopt a distorted trigonal bipyramidal geometry. The cations HPhen+ serve as effective building blocks, strengthening the overall structure through classical hydrogen bonding and additional π-π stacking interactions. Biological screening of (HPhen)4[(μ-O){Ge2(OH) (μ-Tart)2}2]·9H2O demonstrated its remarkable enzyme-effector and antimicrobial activity. The compounds' efficacy can be attributed to the synergistic effects of the independent cations and anions, as well as the ability of protonated 1,10-phenanthroline to inhibit metal ions in enzymes and form stacking interactions with specific protein components. These characteristics make such compounds highly effective and promising antibacterial agents that minimize the risk of developing bacterial resistance.","PeriodicalId":9922,"journal":{"name":"Chemistry Journal of Moldova","volume":null,"pages":null},"PeriodicalIF":0.5000,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Chemistry Journal of Moldova","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.19261/cjm.2023.1121","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"CHEMISTRY, MULTIDISCIPLINARY","Score":null,"Total":0}
引用次数: 0

Abstract

Novel supramolecular cation-anionic coordination compound (HPhen)4[(μ-O){Ge2(OH) (μ-Tart)2}2]·9H2O was synthesised and characterised by the X-ray, elemental, IR- and Hirshfeld surface analysis. It was established that original synthesis method and ability of 1,10-phenanthroline to be protonated promotes the formation of [(μ-O){Ge2(OH)(μ-Tart)2}2]4- anion. In this anion, dimeric fragments are connected by a bridging oxygen atom, and the coordination polyhedra around the germanium atoms adopt a distorted trigonal bipyramidal geometry. The cations HPhen+ serve as effective building blocks, strengthening the overall structure through classical hydrogen bonding and additional π-π stacking interactions. Biological screening of (HPhen)4[(μ-O){Ge2(OH) (μ-Tart)2}2]·9H2O demonstrated its remarkable enzyme-effector and antimicrobial activity. The compounds' efficacy can be attributed to the synergistic effects of the independent cations and anions, as well as the ability of protonated 1,10-phenanthroline to inhibit metal ions in enzymes and form stacking interactions with specific protein components. These characteristics make such compounds highly effective and promising antibacterial agents that minimize the risk of developing bacterial resistance.
阴离子配位菲罗啉酒石酸盐的选择性、合成、晶体结构和生物活性
合成了新型超分子阳离子配位化合物 (HPhen)4[(μ-O){Ge2(OH) (μ-Tart)2}2]-9H2O,并通过 X 射线、元素、红外和 Hirshfeld 表面分析对其进行了表征。结果表明,最初的合成方法和 1,10-菲罗啉的质子化能力促进了[(μ-O){Ge2(OH)(μ-Tart)2}2]4-阴离子的形成。在这种阴离子中,二聚片段通过桥接氧原子连接,锗原子周围的配位多面体采用扭曲的三叉双锥几何形状。阳离子 HPhen+ 可作为有效的构件,通过经典的氢键和额外的 π-π 堆积相互作用加强整体结构。(HPhen)4[(μ-O){Ge2(OH) (μ-Tart)2}2]-9H2O 的生物筛选结果表明,它具有显著的酶作用和抗菌活性。这些化合物的功效可归因于独立阳离子和阴离子的协同作用,以及质子化的 1,10-菲罗啉抑制酶中金属离子和与特定蛋白质成分形成堆叠相互作用的能力。这些特点使得此类化合物成为高效、有前景的抗菌剂,最大程度地降低了细菌产生抗药性的风险。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
求助全文
约1分钟内获得全文 求助全文
来源期刊
Chemistry Journal of Moldova
Chemistry Journal of Moldova CHEMISTRY, MULTIDISCIPLINARY-
CiteScore
0.90
自引率
20.00%
发文量
8
审稿时长
12 weeks
期刊介绍: "Chemistry Journal of Moldova. General, Industrial and Ecological Chemistry" seeks to publish experimental or theoretical research results of outstanding significance and timeliness in all fields of Chemistry, including Industrial and Ecological Chemistry. The main goal of this edition is strengthening the Chemical Society of Moldova, following development of research in Moldovan chemical institutions and promotion of their collaboration with international chemical community. Manuscripts are welcome from all countries.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术官方微信