Study the Effect of Sodium Hyaluronate and Autologous Platelet Rich Fibrin on Symphysis Fracture Healing in Cat

Abstract

This study investigated the impact of sodium hyaluronate and platelet-rich fibrin on the healing process of symphyseal fractures in cats. To conduct this study, 30 adult male cats were utilized and divided into three groups (10 cats each). The groups consisted of a control group (no treatment), a sodium hyaluronate group (treated with sodium hyaluronate gel at the fracture site), and a sodium hyaluronate combined with platelet-rich fibrin group (treated with a mixture of sodium hyaluronate gel and platelet-rich fibrin at the fracture site). The symphysis fractures were induced via a surgical scalpel, and the fractures were then fixed using a cerclage wire. The cats were observed clinically on the first, second, third, and seventh days following the surgery, and Histopathological assessments were conducted 42 days after the surgery. The study showed improvement in the disappearance of swelling in the fracture area among the treated groups. Interestingly, cats were observed to regain the use of their jaws just three days post-surgery, which was not seen in the control group. Histological findings indicate complete fracture healing in the Sodium Hyaluronate-Platelet Rich Fibrin (SH&PRF) group, with active bone remodeling, cartilaginous callus formation, and peripheral fibrous reaction without inflammation. The SH&PRF group showed more active chondrocytes and endochondral ossification than the SH and control groups, suggesting better bone repair results. The study suggests that Sodium Hyaluronate and platelet-rich fibrin composite effectively promote and accelerate wound healing.