THE RELATION BETWEEN MODIFIED SYSTEMIC INFLAMMATION SCORE AND PROGNOSTIC MARKERS OF GASTROINTESTINAL STROMAL TUMORS

SDÜ Tıp Fakültesi Dergisi Pub Date : 2023-12-01 DOI:10.17343/sdutfd.1382872

Fırat Canlikarakaya, Serhat Ocaklı, Cengiz Ceylan, Abidin Göktaş, İlkay Güler, S. Terzioğlu

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Abstract

Objective Gastrointestinal stromal tumours are tumours of mesenchymal origin that can be located along the gastrointestinal tract. In this study, the role of Modified systemic inflammation score in predicting the prognosis of these tumours was investigated. Material and Method 115 patients diagnosed with Gastrointestinal Stromal Tumor (GIST) who underwent surgery at Ankara City Hospital between June 1, 2019 and December 1, 2022 were examined. Tumor location, size, presence of rupture-bleeding-necrosis, Ki-67 level, mitotic index and preoperative albumin, lymphocyte and monocyte levels were evaluated. mSIS score was grouped as 0, 1 and 2. The relationship between mSIS and Ki- 67 index and the presence of rupture, necrosis and bleeding was investigated. Results Out of 115 patients, 68 (59 %) were male, 47 (41 %) were female, with an average age of 62.5 (± 12.67) years. Tumor locations: stomach (64.3 %), small intestine (26 %), colon (5.2 %), esophagus (1.8 %), pancreas (1.8 %), and ovary (0.9 %). Necrosis was in 25 (30.7 %), hemorrhage in 67 (58.7 %), rupture in 19 (16.8 %), and the mean Ki-67 level was 9.09 (± 10.64). 63 (54.8 %) patients had mSIS 0, 29 (25.2 %) had mSIS 1, and 23 (20 %) had mSIS 2. Statistical analysis found a significant correlation between mSIS and necrosis, but not with other parameters. Conclusion The mSIS score is a valuable score showing inflammation in the body and has been shown to be associated with the prognosis of many malignancies. In our study, the presence of necrosis in the tumour was found to be associated with the mSIS score. Although this result alone is not sufficient to predict the prognosis, it is thought to be an issue that may open the door to new studies.

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胃肠道间质瘤的改良系统炎症评分与预后指标之间的关系

目的胃肠道间质瘤是一种间质来源的肿瘤，可位于胃肠道沿线。本研究探讨了修正的全身炎症评分在预测此类肿瘤预后中的作用。材料和方法对2019年6月1日至2022年12月1日期间在安卡拉市医院接受手术的115名确诊为胃肠道间质瘤（GIST）的患者进行了研究。对肿瘤位置、大小、有无破裂出血坏死、Ki-67水平、有丝分裂指数以及术前白蛋白、淋巴细胞和单核细胞水平进行了评估。研究了 mSIS 和 Ki- 67 指数与破裂、坏死和出血之间的关系。结果 115 例患者中，男性 68 例（59%），女性 47 例（41%），平均年龄 62.5（± 12.67）岁。肿瘤位置：胃（64.3%）、小肠（26%）、结肠（5.2%）、食道（1.8%）、胰腺（1.8%）和卵巢（0.9%）。坏死 25 例（30.7%），出血 67 例（58.7%），破裂 19 例（16.8%），Ki-67 平均水平为 9.09（± 10.64）。统计分析发现，mSIS 与坏死之间存在显著相关性，但与其他参数无关。结论 mSIS 评分是显示体内炎症的重要评分，已被证明与许多恶性肿瘤的预后有关。在我们的研究中，发现肿瘤中出现坏死与 mSIS 评分有关。虽然仅凭这一结果不足以预测预后，但这一问题可能会为新的研究打开大门。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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