A Review of Current Clinical Research on Herbal Monotherapy for Coronavirus Disease-19 (COVID-19)

Journal of Korean Medicine Pub Date : 2023-12-01 DOI:10.13048/jkm.23057

Jee Won Shon, Do Kyung Han, Won Gun An

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Abstract

Objectives: The purpose of this study was to evaluate the effectiveness and safety of traditional herbal medicine as a stand-alone treatment group through major English databases due to the lack of RCTs in Korea, and to provide a review of the herbal interventions used.Methods: Using four databases (Pubmed, EMBASE, OASIS, RISS), combination of words such as “Coronavirus” “RCT” “Herb” “Decoction” “TCM” were used. RCTs using herbal medicines to treat coronavirus were searched. Final 4 studies were selected by two authors according to inclusion and exclusion criteria.Results: A total of 1,435 patients were studied. The Chinese herbs used in the treatment group were Shengmai Yin, JingYinGuBiao granules, Jinhua Qinggan granules, and Bufei Huoxue capsules. The intervention group showed greater attenuation of pneumonia lesions on CT. Also, improvement in 6-min walk distance (6MWD), and negative conversion rate in treatment group were reported. Furthermore, scores on the Fatigue Assessment Inventory (FAI) were lower in the herbal group than in the placebo group. The median time to recovery of COVID-19 related symptoms was shorter in TCM group compared to the control group. Reported adverse effects were diarrhea, liver dysfunction, and excessive menstruation, and two papers did not mention side effects in detail.Conclusion: Herbal medicine alone can increase the conversion rate of viral negativity and relieve COVID-19 related symptoms without significant adverse effects.

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冠状病毒病-19（COVID-19）中草药单一疗法的临床研究综述

研究目的由于韩国缺乏 RCT，本研究旨在通过主要英文数据库评估传统草药作为独立治疗组的有效性和安全性，并对所使用的草药干预措施进行综述：方法：利用四个数据库（Pubmed、EMBASE、OASIS、RISS），将 "冠状病毒""RCT""草药""煎剂""中医 "等词进行组合。检索了使用草药治疗冠状病毒的 RCT。最后由两位作者根据纳入和排除标准选出了 4 项研究：共有 1,435 名患者接受了研究。治疗组使用的中药为生脉散、养阴清热颗粒、金花清热颗粒和藿香正气胶囊。干预组在 CT 上显示肺炎病灶有更大的衰减。此外，治疗组的 6 分钟步行距离（6MWD）和负转阴率也有所改善。此外，中药组的疲劳评估量表（FAI）得分低于安慰剂组。与对照组相比，中药组恢复 COVID-19 相关症状的中位时间更短。报告的不良反应为腹泻、肝功能异常和月经过多，两篇论文未详细提及副作用：结论：单用中药可提高病毒阴转率，缓解 COVID-19 相关症状，且无明显不良反应。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Journal of Korean Medicine

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