A case of plasmacytoma with widespread metastasis in a dog

Osman Dagar, Aysenur Tural, Zeynep Celik, Fatih Mehmet Ozturk, Mehmet Tuzcu, Erhan Gulcicek
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Abstract

In this study, a case of plasmacytoma with widespread metastasis in a nine-year-old male Rottweiler dog was described by histopathological and immunohistochemical methods. Macroscopic examination revealed multifocal white or pink-red colored masses ranging in size from 0,5 to 3 cm in the lung, liver, mediastinal and mesenterial lymph nodes, spleen, heart, pancreas, intestine and kidneys. In microscopic examination, tumor foci consisting mostly of atypical plasma cells were observed in the lung, liver, spleen, pancreas, mediastinal and mesenteric lymph nodes, intestine, and kidneys. Tumor-type giant cells were observed in tumor foci in the lung, mitotic figures in tumor foci in other organs, including the lung, and abundant tumor cells in capillary vessels. In Methyl Green Pyronin staining of lung, liver, spleen, pancreas, mediastinal and mesenterial lymph nodes, intestine and kidney sections, the cytoplasm of plasma cells was observed to be stained pink. Congo Red staining applied to liver and spleen sections showed amyloid deposits stained in brick red color. In addition, in the immunohistochemical staining of lung, liver, spleen, pancreas, mediastinal and mesenterial lymph nodes, intestine and kidney sections with Proliferating Cell Nuclear Antigen (PCNA) antibody, severe immunoreactivity was detected in tumor cells. As a result, due to the presence of rarely reported widespread metastases in the lung, liver, spleen, pancreas, mediastinal and mesenterial lymph nodes, intestine and kidneys of the diagnosed plasmacytoma case, it was deemed appropriate to publish the case in order to contribute to the literature by attracting the attention of veterinarians.
一例伴有广泛转移的狗浆细胞瘤
本研究采用组织病理学和免疫组化方法描述了一例9岁雄性罗威纳犬浆细胞瘤并广泛转移的病例。宏观检查发现,在肺、肝脏、纵隔和肠系膜淋巴结、脾脏、心脏、胰腺、肠道和肾脏中存在多灶性白色或粉红色肿块,大小从 0.5 厘米到 3 厘米不等。显微镜检查发现,肺、肝、脾、胰腺、纵隔和肠系膜淋巴结、肠道和肾脏中的肿瘤病灶主要由非典型浆细胞组成。在肺部的肿瘤灶中观察到肿瘤型巨细胞,在包括肺部在内的其他器官的肿瘤灶中观察到有丝分裂图形,在毛细血管中观察到大量肿瘤细胞。在肺部、肝脏、脾脏、胰腺、纵隔和肠系膜淋巴结、肠道和肾脏切片的甲基绿原酸染色中,浆细胞的细胞质被染成粉红色。肝脏和脾脏切片的刚果红染色显示淀粉样沉积物呈砖红色。此外,用增殖细胞核抗原(PCNA)抗体对肺、肝、脾、胰腺、纵隔和肠系膜淋巴结、肠和肾切片进行免疫组化染色时,在肿瘤细胞中发现了严重的免疫反应性。因此,鉴于该例浆细胞瘤在肺部、肝脏、脾脏、胰腺、纵隔和肠系膜淋巴结、肠道和肾脏出现广泛转移的罕见报道,我们认为应该公布该病例,以引起兽医的注意,为文献做出贡献。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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