Thyroid Hormone Status in Severely Malnourished Children between 6 Months to 5 Years Admitted to Nutritional Rehabilitation Centre of a Tertiary Care Hospital

IF 0.1 Q4 PEDIATRICS
Anita Mehta, Ashish Kushwaha, Ankur Kumar, Kuldeep Singh, Ajeet Yadav
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Abstract

Introduction: Severe malnutrition poses a significant risk to the thyroid gland's function and hormonal balance, which can lead to numerous physiological and developmental complications. Understanding the relationship between severe malnutrition and thyroid hormone status is crucial for the effective management of these children. Aim and Objective: To investigate the prevalence and patterns of thyroid hormone abnormalities in severely malnourished patients with subgroup analysis in Marasmus, Kwashiorkor, and edematous malnourished patients. Methodology: We conducted a cross-sectional study involving 116 children diagnosed with severe acute malnutrition (SAM). The study protocol was approved by the Institution Ethics Committee. Well-informed written consent in the local language was taken from parents. SAM was diagnosed and managed according to WHO criteria (1). Comprehensive laboratory investigations were conducted to assess serum levels of thyroid-stimulating hormone (TSH), free thyroxine (T4), and triiodothyronine (T3). Statistical analysis was performed to examine the associations between these variables and SAM. Results: Most of the 116 subjects included in the study were male (53.4%) and had a lower socioeconomic status (43.9%). The age distribution of the children aged below 5 years revealed that 46.5% were between 12 and 36 months old. In the present study, Marasmus was 55.2%, Kwashiorkor was 12.1%, and edematous malnutrition was 32.7%. Among 116 participants, 94.8% were discharged, while 5.2% were expired during treatment. The mean levels of fT3, fT4, and TSH were 1.88±1.06 pg/ml, 0.99±0.84 ng/dl, and 3.22±0.87 µIU/ml, respectively. Most SAM patients had low fT3, fT4, and TSH levels relative to the normal range. Conclusion: Monitoring of thyroid hormone status in SAM patients is mandatory for this vulnerable population.
一家三甲医院营养康复中心收治的 6 个月至 5 岁严重营养不良儿童的甲状腺激素状况
简介严重营养不良对甲状腺的功能和激素平衡构成重大威胁,可导致多种生理和发育并发症。了解严重营养不良与甲状腺激素状态之间的关系对于有效管理这些儿童至关重要。 目的和目标研究严重营养不良患者甲状腺激素异常的发生率和模式,并对马拉斯穆斯、夸氏营养不良和水肿性营养不良患者进行亚组分析。 研究方法我们对116名确诊为严重急性营养不良(SAM)的儿童进行了横断面研究。研究方案获得了机构伦理委员会的批准。我们用当地语言征得了家长知情的书面同意。严重急性营养不良症的诊断和处理符合世界卫生组织的标准 (1)。研究人员进行了全面的实验室检查,以评估血清中促甲状腺激素(TSH)、游离甲状腺素(T4)和三碘甲状腺原氨酸(T3)的水平。对这些变量与 SAM 之间的关系进行了统计分析。 研究结果参与研究的 116 名受试者中,大多数为男性(53.4%),社会经济地位较低(43.9%)。5岁以下儿童的年龄分布显示,46.5%的儿童年龄在12至36个月之间。在本研究中,55.2%的儿童患有马拉氏症,12.1%的儿童患有卡氏症,32.7%的儿童患有水肿性营养不良。在116名参与者中,94.8%已出院,5.2%在治疗期间死亡。fT3、fT4和促甲状腺激素的平均水平分别为1.88±1.06 pg/ml、0.99±0.84 ng/dl和3.22±0.87 µIU/ml。与正常范围相比,大多数 SAM 患者的 fT3、fT4 和 TSH 水平较低。 结论对这一易感人群来说,监测 SAM 患者的甲状腺激素水平是必须的。
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CiteScore
0.60
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19
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