Fabrication of Interpenetrating Polymer Network-Based Hydrogel for Colon-Targeted Release of Nateglinide

Q3 Pharmacology, Toxicology and Pharmaceutics

Jordan Journal of Pharmaceutical Sciences Pub Date : 2023-12-25 DOI:10.35516/jjps.v16i4.775

Daxaben Kothiya, Subhash S. Vaghani

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Abstract

Nateglinide is an anti-diabetic agent that experiences modest first-pass metabolism and poor aqueous solubility. This paper explores the preparation, characterization, and evaluation of interpenetrating polymer network composite hydrogels of chitosan and poly(meth(methacrylic)) acid as a potential carrier for the drug. Interpenetrating polymer network composite hydrogels of chitosan and poly(meth(methacrylic) acid incorporating nateglinide were prepared using N,Nꞌ-methylene bisacrylamide and glutaraldehyde as cross-linkers. The polymerization of chitosan, entrapment of the drug, and its interaction in prepared hydrogels were checked by FTIR spectroscopy, DSC, and powder XRD studies. The hydrogels were evaluated for their swelling behavior and in vitro drug release. The morphology of the hydrogels before and after dissolution was studied using SEM. The hydrogels showed a 93.29 ± 4.65% yield and 91.28 ± 2.22% drug loading. The hydrogels exhibited pH-sensitive swelling behavior. The in vitro release profile confirmed that the drug release depended on the swelling of hydrogels and showed a biphasic release pattern. Chitosan-poly(meth(methacrylic)) acid interpenetrating polymer network hydrogel, with its biodegradable nature and pH-sensitive release of nateglinide, is an attractive option to be further explored for targeted controlled drug delivery formulations for the drug.

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制作基于互穿聚合物网络的水凝胶，实现纳格列奈的结肠靶向释放

纳格列奈是一种抗糖尿病药物，具有适度的首过代谢和较差的水溶性。本文探讨了壳聚糖和聚甲基丙烯酸互穿聚合物网络复合水凝胶作为该药物潜在载体的制备、表征和评估。以 N,Nꞌ-亚甲基双丙烯酰胺和戊二醛为交联剂，制备了含有纳格列奈的壳聚糖和聚甲基丙烯酸互穿聚合物网络复合水凝胶。通过傅立叶变换红外光谱、DSC 和粉末 XRD 研究检测了壳聚糖的聚合、药物的包埋及其在制备的水凝胶中的相互作用。对水凝胶的溶胀行为和体外药物释放进行了评估。使用扫描电镜研究了水凝胶溶解前后的形态。水凝胶的产率为 93.29 ± 4.65%，药物负载率为 91.28 ± 2.22%。水凝胶表现出对 pH 值敏感的溶胀行为。体外释放曲线证实，药物释放取决于水凝胶的溶胀，并呈现双相释放模式。壳聚糖-聚甲基丙烯酸互穿聚合物网络水凝胶具有生物可降解性和对 pH 值敏感的纳格列奈释放特性，是一种有吸引力的选择，值得进一步探索用于该药物的靶向控制给药配方。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Jordan Journal of Pharmaceutical Sciences Pharmacology, Toxicology and Pharmaceutics-Pharmaceutical Science

CiteScore

1.70

自引率

0.00%

发文量

期刊介绍： The Jordan Journal of Pharmaceutical Sciences (JJPS) is a scientific, bi-annual, peer-reviewed publication that will focus on current topics of interest to the pharmaceutical community at large. Although the JJPS is intended to be of interest to pharmaceutical scientists, other healthy workers, and manufacturing processors will also find it most interesting and informative. Papers will cover basic pharmaceutical and applied research, scientific commentaries, as well as views, reviews. Topics on products will include manufacturing process, quality control, pharmaceutical engineering, pharmaceutical technology, and philosophies on all aspects of pharmaceutical sciences. The editorial advisory board would like to place an emphasis on new and innovative methods, technologies, and techniques for the pharmaceutical industry. The reader will find a broad range of important topics in this first issue.