Correlation of Thyroid Stimulating Hormone (TSH), T3, and T4 Hormones with Histopathological Characteristics of Thyroid Cancer at Cipto Mangunkusumo General Hospital

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Abstract

Introduction. In a study spanning 2008 to 2012 at Cipto Mangunkusumo General Hospital (CMGH) Jakarta, 668 cases of thyroid cancer were identified among 18,216 cancer cases. Globally, the papillary subtype is prevalent, and prior research indicates a link between thyroid hormone changes and thyroid carcinoma risk. To improve surgical care, this study aims to find the association between thyroid hormone levels and histological subtypes in thyroid carcinoma patients. Method. This cross-sectional study focused on thyroid cancer patients managed from 2013 to 2017. Despite subjects' characteristics, thyroid hormone levels and histopathological findings were the variables of interest. The findings were analyzed using ANOVA, Kruskal-Wallis, unpaired T-tests, Mann-Whitney tests, and Pearson or Spearman tests to find correlations with age, gender, clinical presentation, and body mass index. Results. The mean age was 48.7 years, with subjects having an average body weight of 64.5 kg, height of 154.4 cm, and BMI of 24.8 kg/m2. Hormonal analysis revealed mean T3 levels at 2.02 ng/mL, T4 levels were slightly lower at 1.92 ng/mL, and TSH levels were the lowest at 1.22 ng/mL. A very weak correlation existed between the T3 hormone and age (r = 0.05, p = 0.77). In the correlation between T4 thyroid hormone levels and age, a weak correlation was found between T4 thyroid hormone levels and age (r = 0.31, p = 0.08). In the correlation between thyroid cancer histopathology and gender, clinical presentation, and BMI, there was no significant association with gender, 𝑟s = 0,01; 95% 𝐵𝐶𝑎 [-3,37; 3.34]; p=0,94 Conclusion. This study indicates that the TSH, T3, and T4 hormone levels were not associated with the histopathological characteristics of thyroid cancer at CMGH. The T3, T4, and TSH hormone levels were unaffected by gender, nodule involvement, and age.
Cipto Mangunkusumo 综合医院甲状腺刺激素(TSH)、T3 和 T4 激素与甲状腺癌组织病理学特征的相关性
简介雅加达Cipto Mangunkusumo综合医院(CMGH)在2008年至2012年期间开展了一项研究,在18216例癌症病例中发现了668例甲状腺癌。在全球范围内,乳头状亚型甲状腺癌非常普遍,先前的研究表明甲状腺激素变化与甲状腺癌风险之间存在联系。为了改善手术护理,本研究旨在发现甲状腺癌患者的甲状腺激素水平与组织学亚型之间的关联。研究方法这项横断面研究主要针对2013年至2017年期间接受治疗的甲状腺癌患者。尽管受试者的特征、甲状腺激素水平和组织病理学结果是研究的变量。研究结果采用方差分析、Kruskal-Wallis、非配对T检验、Mann-Whitney检验、Pearson或Spearman检验进行分析,以找出与年龄、性别、临床表现和体重指数的相关性。研究结果受试者的平均年龄为 48.7 岁,平均体重为 64.5 公斤,身高为 154.4 厘米,体重指数为 24.8 公斤/平方米。激素分析显示,T3 的平均水平为 2.02 纳克/毫升,T4 水平略低,为 1.92 纳克/毫升,促甲状腺激素水平最低,为 1.22 纳克/毫升。T3 激素与年龄之间存在极弱的相关性(r = 0.05,p = 0.77)。在T4甲状腺激素水平与年龄的相关性方面,发现T4甲状腺激素水平与年龄之间存在微弱的相关性(r = 0.31,p = 0.08)。在甲状腺癌组织病理学与性别、临床表现和体重指数的相关性中,性别没有显著相关性,𝑟s = 0,01; 95% 𝐵𝐶𝑎 [-3,37; 3.34]; p=0,94 结论。本研究表明,TSH、T3和T4激素水平与CMGH甲状腺癌的组织病理学特征无关。T3、T4和TSH激素水平不受性别、结节受累情况和年龄的影响。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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