A 4-week Randomized, Double-Blind, Placebo-Controlled Clinical Trial on the Use of Grape Seed Extract for Reducing Plasma Glucose, Lipid Profile, and Blood Pressure in Patients with Type 2 Diabetes Mellitus

IF 1 Q4 PHARMACOLOGY & PHARMACY
N. Zaeemzadeh, Marzieh Alavifar, Amal Saki Malehi, Mehrnoosh Zakerkish
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Abstract

: Diabetes mellitus (DM) is a common chronic disease that can significantly reduce life expectancy due to its complications. Grapes (Vitis vinifera L.) and their byproducts, including grape seeds, have been used worldwide for the treatment of various ailments. This clinical trial investigated the effect of grape seed extract (GSE) on fasting blood sugar (FBS), lipid profile (including total cholesterol, high-density lipoprotein [HDL], low-density lipoprotein [LDL], and triglycerides [TG]), and systolic blood pressure (SBP) and diastolic blood pressure (DBP) in patients with type 2 diabetes mellitus (T2DM). A total of 74 patients with T2DM were divided into two groups, including 38 patients in the treatment (GSE) group receiving 263.2 mg of GSE (standardized to 250 mg proanthocyanidin) twice daily and 36 patients in the placebo (control) group receiving 263.2 mg of the placebo twice daily for 30 days. At the end of the intervention, a statistically significant decrease was observed in SBP (from 125.83 ± 13.39 in the placebo group to 121.94 ± 7.49 in the treatment group, P = 0.002) and FBS (from 144.75 ± 30.82 in the placebo group to 129.87 ± 31.79 in the treatment group, P = 0.001). However, there were no significant changes in total cholesterol, HDL, LDL, TG, and DBP between the two groups. The use of Iranian GSE for a short period might lead to lower FBS and SBP. Therefore, GSE might play a significant role in improving blood pressure and fasting blood glucose levels in patients with T2DM.
葡萄籽提取物降低 2 型糖尿病患者血浆葡萄糖、血脂和血压的 4 周随机、双盲、安慰剂对照临床试验
:糖尿病(DM)是一种常见的慢性疾病,其并发症会大大缩短患者的寿命。葡萄(Vitis vinifera L.)及其副产品,包括葡萄籽,一直被世界各地用于治疗各种疾病。这项临床试验研究了葡萄籽提取物(GSE)对 2 型糖尿病(T2DM)患者空腹血糖(FBS)、血脂(包括总胆固醇、高密度脂蛋白[HDL]、低密度脂蛋白[LDL]和甘油三酯[TG])、收缩压(SBP)和舒张压(DBP)的影响。共有 74 名 T2DM 患者被分为两组,其中治疗(GSE)组 38 名患者每天两次服用 263.2 毫克 GSE(标准化为 250 毫克原花青素),安慰剂(对照)组 36 名患者每天两次服用 263.2 毫克安慰剂,连续服用 30 天。干预结束时,SBP(从安慰剂组的 125.83 ± 13.39 降至治疗组的 121.94 ± 7.49,P = 0.002)和 FBS(从安慰剂组的 144.75 ± 30.82 降至治疗组的 129.87 ± 31.79,P = 0.001)均有统计学意义的显著下降。不过,两组之间的总胆固醇、高密度脂蛋白、低密度脂蛋白、总胆固醇和 DBP 没有明显变化。短期使用伊朗 GSE 可能会降低 FBS 和 SBP。因此,GSE 可能会在改善 T2DM 患者的血压和空腹血糖水平方面发挥重要作用。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
CiteScore
1.40
自引率
0.00%
发文量
26
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