{"title":"The Coexistence of Fibromuscular Dysplasia of the Renal Artery and Graves’ Disease in an Adolescent: A Case Report","authors":"Jinsol Jeong, Haesook Kim, Dongwon Lee","doi":"10.15746/sms.23.013","DOIUrl":null,"url":null,"abstract":"Here we present a rare case of an adolescent with hypertension, concurrently diagnosed with fibromuscular dysplasia of the renal artery and Graves’ disease. Although fibromuscular dysplasia and Graves’ disease have distinct pathogenic mechanisms, it is possible to infer the potential correlation between the two from the perspective of vascular involvement. It is believed that transforming growth factor-β, as the shared element of both diseases, may contribute to their development and progression. The overactivation of the sympathetic nervous system in Graves’ disease may induce hyperplasia of vascular smooth muscle cells, similar to that observed in fibromuscular dysplasia. In Graves’ disease, the excessive synthesis and secretion of angiotensin II due to the overactivation of the renin-angiotensin system, along with the up-regulation of angiotensin II receptors, may also induce pathological changes in the vasculature throughout the body. In this regard, exploring the correlation between fibromuscular dysplasia and Graves’ disease is of significant clinical importance.","PeriodicalId":22016,"journal":{"name":"Soonchunhyang Medical Science","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"2023-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Soonchunhyang Medical Science","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.15746/sms.23.013","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0
Abstract
Here we present a rare case of an adolescent with hypertension, concurrently diagnosed with fibromuscular dysplasia of the renal artery and Graves’ disease. Although fibromuscular dysplasia and Graves’ disease have distinct pathogenic mechanisms, it is possible to infer the potential correlation between the two from the perspective of vascular involvement. It is believed that transforming growth factor-β, as the shared element of both diseases, may contribute to their development and progression. The overactivation of the sympathetic nervous system in Graves’ disease may induce hyperplasia of vascular smooth muscle cells, similar to that observed in fibromuscular dysplasia. In Graves’ disease, the excessive synthesis and secretion of angiotensin II due to the overactivation of the renin-angiotensin system, along with the up-regulation of angiotensin II receptors, may also induce pathological changes in the vasculature throughout the body. In this regard, exploring the correlation between fibromuscular dysplasia and Graves’ disease is of significant clinical importance.
我们在这里介绍一例罕见的青少年高血压患者,他同时被诊断出患有肾动脉纤维肌性发育不良和巴塞杜氏病。虽然纤维肌性发育不良和巴塞杜氏病的致病机制不同,但从血管受累的角度可以推断出两者之间潜在的相关性。据认为,转化生长因子-β作为这两种疾病的共同因素,可能有助于它们的发展和恶化。巴塞杜氏病中交感神经系统的过度活跃可能会诱发血管平滑肌细胞的增生,这与纤维肌肉发育不良症中观察到的情况类似。在巴塞杜氏病中,由于肾素-血管紧张素系统的过度激活,血管紧张素 II 合成和分泌过多,再加上血管紧张素 II 受体的上调,也可能诱发全身血管的病理变化。因此,探讨纤维肌发育不良与巴塞杜氏病之间的相关性具有重要的临床意义。