Comparison of Complication and Post-Operative Infection Rate Between Application of Carbetocin and Oxytocin during Management of Post-Partum Hemorrhage after Caesarean Section

Bangladesh Journal of Infectious Diseases Pub Date : 2023-12-31 DOI:10.3329/bjid.v10i2.70542

Farhana Haque Choudhury, Mosammat Salma Noor, Syeda Tania Tanzin, Shahnaz Ahmed, Naheed Fatema

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Abstract

Background: Adverse effects can be produced by carbetocin and oxytocin during management of post-partum hemorrhage after caesarean section. Objective: The purpose of the present study was to compare the adverse effects among women with post-partum hemorrhage after caesarean section. Methodology: This randomized controlled trial was conducted in the Department of Obstetrics and Gynaecology at Bangabandhu Sheikh Mujib Medical University (BSMMU), Dhaka, Bangladesh from July 2015 to December 2015 for a period of six months. Pregnant women diagnosed on the standard criteria admitted in BSMMU, Dhaka, Bangladesh were selected as study population by consecutive type of sampling. Randomization was performed according to computer generated simple random sampling method. An Uterotonic was an agent used to induce contraction or greater tonicity of the uterus. Then the patients were monitored per operatively and post operatively. All the information was recorded in data collection sheet. Main outcome variables were estimated blood loss. Results: A total number of 96 pregnant women were recruited for this study of which 48 cases were enrolled in group I and the rest of 48 case were enrolled in group II. The mean age with SD of the group I and group II were 24.4±4.7 years and 24.7±3.7 years. In blood transfusion of the study patients, 2(4.2%) patients need blood transfusion in group I and 5(10.4%) in group II (p>0.05). One (2.1%) patients had anaemia in group I and 5(10.4%) in group II. Forty-six (95.8%) patients had average menstrual flow in group I and 40(83.3%) in group II (p>0.05). Considering the side effect, 1(2.1%) patients had nausea in group I and 4(8.3%) in group II. Two (4.2%) patients had vomiting in group I and 5(10.4%) in group II. One (2.1%) patients had headache in group I and 4(8.3%) in group II. Four (8.3%) patients had infection rate in group I and 5(10.4%) in group II (p>0.05). Conclusion: In conclusion blood transfusion, anaemia, vomiting and infection rate are found less in group I than group II. Bangladesh Journal of Infectious Diseases, December 2023;10(2):59-64

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在处理剖腹产后出血时使用卡贝缩宫素和催产素的并发症和术后感染率比较

背景：在处理剖腹产后产后出血时，卡贝缩宫素和催产素可能会产生不良反应。研究目的本研究旨在比较剖腹产产后出血妇女的不良反应。研究方法：本随机对照试验于 2015 年 7 月至 2015 年 12 月在孟加拉国达卡班加班杜谢赫-穆吉布医科大学（BSMMU）妇产科进行，为期 6 个月。孟加拉国达卡班加胡谢赫-穆吉布医科大学根据标准标准诊断出的孕妇通过连续抽样方式被选中作为研究对象。随机抽样根据计算机生成的简单随机抽样法进行。子宫收缩剂是一种用于诱导子宫收缩或增强子宫张力的药物。然后对患者进行术前和术后监测。所有信息都记录在数据收集表中。主要结果变量为估计失血量。结果本研究共招募了 96 名孕妇，其中 48 例被纳入第一组，其余 48 例被纳入第二组。第一组和第二组的平均年龄（标清）分别为（24.4±4.7）岁和（24.7±3.7）岁。在输血方面，I 组有 2 例（4.2%）患者需要输血，II 组有 5 例（10.4%）患者需要输血（P>0.05）。第一组中有 1 名（2.1%）患者贫血，第二组中有 5 名（10.4%）患者贫血。第一组有 46 名（95.8%）患者月经量一般，第二组有 40 名（83.3%）患者月经量一般（P>0.05）。在副作用方面，I 组有 1 名（2.1%）患者出现恶心，II 组有 4 名（8.3%）患者出现恶心。第一组有 2 名（4.2%）患者出现呕吐，第二组有 5 名（10.4%）患者出现呕吐。第一组和第二组分别有 1 名（2.1%）和 4 名（8.3%）患者出现头痛。I 组有 4 名（8.3%）患者出现感染，II 组有 5 名（10.4%）患者出现感染（P>0.05）。结论总之，第一组的输血、贫血、呕吐和感染率均低于第二组。孟加拉国传染病杂志》，2023 年 12 月；10（2）：59-64

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Bangladesh Journal of Infectious Diseases

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