The effect of Norethisterone Acetate (NETA) on the ovarian follicles of albino rats: Histological Study.

Abstract

: Background: Norethisterone, also known as Norethisterone Acetate (NETA), or Norethindrone, is a commonly used pro-gestogen in various European countries. Aim of the Work: Previous studies have shown that introducing synthetic hormones can alter the effects of sex hormones on the ovarian cycle and lead to negative outcomes for the ovaries. There is a lack of histological reports regarding the effects of NETA on the ovarian morphology. So, the present study focuses on the ovarian histological sequelae following the exposure to NETA in the albino rats. Materials and Methods : Fourteen adult female albino rats were investigated. They were randomly divided into two groups: Control group (A) and NETA treated group (B). Each one consisted of 7 rats. Albino rats of control group (A) were administered daily food and distilled water only, while rats of NETA treated group (B) were administered daily 20 µg of NETA dissolved in 2 ml distilled water, food, and water. The experiment was continued for three weeks. Results: The findings indicate that the use of NETA has negative effects on the ovarian follicles, including a reduction in their number and signs of atresia across all stages. Conclusion: This treatise underscored Norethisterone Acetate (NETA) has an adverse effect on the ovarian cycle and follicular development of the albino rat.