Daylight Saving Time Practice and the Rate of Adverse Cardiovascular Events in the United States: A Probabilistic Assessment in a Large Nationwide Study

Benjamin A. Satterfield MD, PhD , Ozan Dikilitas MD , Holly Van Houten BA , Xiaoxi Yao PhD, MPH , Bernard J. Gersh MBChB, DPhil
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Abstract

We investigated the association of daylight saving time (DST) transitions with the rates of adverse cardiovascular events in a large, US-based nationwide study. The study cohort included 36,116,951 unique individuals from deidentified administrative claims data of the OptumLabs Data Warehouse. There were 74,722 total adverse cardiovascular events during DST transition and the control weeks (2 weeks before and after) in spring and autumn of 2015-2019. We used Bayesian hierarchical Poisson regression models to estimate event rate ratios representing the ratio of composite adverse cardiovascular event rates between DST transition and control weeks. There was an average increase of 3% (95% uncertainty interval, −3% to −10%) and 4% (95% uncertainty interval, −2% to −12%) in adverse cardiovascular event rates during Monday and Friday of the spring DST transition, respectively. The probability of this being associated with a moderate-to-large increase in the event rates (estimate event rate ratio, >1.10) was estimated to be less than 6% for Monday and Friday, and less than 1% for the remaining days. During autumn DST transition, the probability of any decrease in adverse cardiovascular event rates was estimated to be less than 46% and a moderate-to-large decrease in the event rates to be less than 4% across all days. Results were similar when adjusted by age. In conclusion, spring DST transition had a suggestive association with a minor increase in adverse cardiovascular event rates but with a very low estimated probability to be of clinical importance. Our findings suggest that DST transitions are unlikely to meaningfully impact the rate of cardiovascular events.

美国的夏令时做法与不良心血管事件发生率:一项大型全国性研究的概率评估
我们在一项大型的美国全国性研究中调查了夏令时(DST)转换与不良心血管事件发生率之间的关系。研究队列包括 OptumLabs 数据仓库中 36,116,951 名来自去标识化行政索赔数据的独特个体。在 2015 年春季和 2019 年秋季的 DST 过渡期和对照周(前后 2 周)期间,共发生了 74,722 起不良心血管事件。我们使用贝叶斯分层泊松回归模型估算了事件发生率比,该比率代表了 DST 过渡周和对照周之间的心血管不良事件综合发生率比。在春季夏令时过渡期的周一和周五,不良心血管事件发生率分别平均增加了 3%(95% 不确定区间,-3% 至 -10%)和 4%(95% 不确定区间,-2% 至 -12%)。据估计,这与事件发生率的中度至大幅上升(估计事件发生率比值,>1.10)有关的概率在周一和周五小于 6%,在其余日期小于 1%。在秋季夏令时过渡期间,心血管不良事件发生率下降的概率估计小于 46%,所有日期的事件发生率中度至大幅下降的概率估计小于 4%。根据年龄进行调整后,结果类似。总之,春季夏令时转换与心血管不良事件发生率的轻微增加有提示性关联,但具有临床重要性的估计概率非常低。我们的研究结果表明,夏令时转换不太可能对心血管事件的发生率产生有意义的影响。
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来源期刊
Mayo Clinic proceedings. Innovations, quality & outcomes
Mayo Clinic proceedings. Innovations, quality & outcomes Surgery, Critical Care and Intensive Care Medicine, Public Health and Health Policy
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