Can Inflammation Indices Preoperatively Predict Acute Kidney Injury after Cardiac Surgery?

IF 0.7 4区医学 Q4 CARDIAC & CARDIOVASCULAR SYSTEMS

Heart Surgery Forum Pub Date : 2023-12-26 DOI:10.59958/hsf.6767

Serkan Yildirim

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引用次数: 0

Abstract

Background: Coronary artery disease is a condition characterized by atherosclerosis and inflammation in the vessel wall. In patient undergoing surgery, a systemic inflammatory-like condition occurs in the postoperative period through mediators that develop due to acute stress.

Methods: 581 patients enrolled from the hospital records from 2019 and 2022 retrospectively. Systemic immune inflammation index (SII), systemic inflammation response index (SIRI) and aggregated index of systemic inflammation (AISI) values were calculated from peripheral blood samples taken at hospital admission using the formula SII = platelet (P) × neutrophil (N) / lymphocyte (L), SIRI = N × monocyte (M) / L, AISI = (N × M × P) / L.

Results: The mean age of the 581 patients included in the study was 63.97 ± 8.77 years. 45% of the patients were women. Mean cardio-pulmonary bypass time (CPBT) was 100.31 ± 31.94 and mean cross-clamp time (CCT) was 59.79 ± 24.07. When the correlation of acute kidney injury (AKI) development was analyzed with the variables (P/L ratio, N/L ratio, SII, SIRI, AISI, CCT and CPBT), all variables we tested and age were found to be significantly correlated (p < 0.01).

Conclusion: We think that the calculations we tested in our study, together with the understanding of the complexity of the inflammatory system, will constitute an important step in the detection of AKI.

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术前炎症指标能否预测心脏手术后的急性肾损伤？

背景：冠状动脉疾病是一种以血管壁动脉粥样硬化和炎症为特征的疾病。在接受手术的患者中，由于急性应激导致的介质作用，术后会出现类似全身炎症的情况。根据入院时采集的外周血样本计算全身免疫炎症指数（SII）、全身炎症反应指数（SIRI）和全身炎症聚集指数（AISI）值，计算公式为：SII=血小板（P）×中性粒细胞（N）/淋巴细胞（L），SIRI=N×单核细胞（M）/L，AISI=（N×M×P）/L：参与研究的 581 名患者的平均年龄为（63.97 ± 8.77）岁。45%的患者为女性。平均心肺旁路时间（CPBT）为（100.31 ± 31.94），平均交叉钳夹时间（CCT）为（59.79 ± 24.07）。在分析急性肾损伤（AKI）发生与变量（P/L 比值、N/L 比值、SII、SIRI、AISI、CCT 和 CPBT）的相关性时，发现我们测试的所有变量与年龄都有显著相关性（P < 0.01）：我们认为，我们在研究中测试的计算方法，加上对炎症系统复杂性的了解，将成为检测 AKI 的重要一步。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Heart Surgery Forum 医学-外科

CiteScore

1.20

自引率

16.70%

发文量

130

审稿时长

6-12 weeks

期刊介绍： The Heart Surgery Forum® is an international peer-reviewed, open access journal seeking original investigative and clinical work on any subject germane to the science or practice of modern cardiac care. The HSF publishes original scientific reports, collective reviews, case reports, editorials, and letters to the editor. New manuscripts are reviewed by reviewers for originality, content, relevancy and adherence to scientific principles in a double-blind process. The HSF features a streamlined submission and peer review process with an anticipated completion time of 30 to 60 days from the date of receipt of the original manuscript. Authors are encouraged to submit full color images and video that will be included in the web version of the journal at no charge.