Meeting report of the 4th European biotransformation workshop.

IF 1.3 4区医学 Q4 PHARMACOLOGY & PHARMACY

Xenobiotica Pub Date : 2024-05-01 Epub Date: 2024-01-17 DOI:10.1080/00498254.2024.2302547

M Walles, A Pähler, E M Isin, Marie M Ahlqvist

引用次数: 0

Abstract

1. Challenges, strategies and new technologies in the field of biotransformation were presented and discussed at the fourth European Biotransformation Workshop which was held in collaboration with the joint ISSX/DMDG meeting on June 15, 2023 at the University of Hertfordshire in Hatfield, UK.2. In this meeting report we summarise the presentations and discussions from this workshop.3. The topics covered are listed below: Unusual biotransformation reactionsBiotransformation Workflows in Discovery utilising various softwares for structure elucidationBiotransformation software for the identification of peptide metabolitesAccelerator Mass Spectrometry (AMS) for endogenous and xenobiotic metabolite profilingMetabolite profiling using quantitative Nuclear magnetic resonance (NMR) and liquid chromatography coupled to inductively coupled plasma-mass spectrometry (LC-ICP-MS).

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第四届欧洲生物转化研讨会会议报告。

2023 年 6 月 15 日，在英国哈特菲尔德的赫特福德大学举行了第四届欧洲生物转化研讨会，该研讨会与国际空间科学与技术协会/DMDG 联席会议合作举办，会上介绍并讨论了生物转化领域的挑战、战略和新技术。在本会议报告中，我们总结了此次研讨会的发言和讨论情况。涉及的主题如下：非同寻常的生物转化反应利用各种软件进行结构阐释的发现中的生物转化工作流程鉴定肽类代谢物的生物转化软件用于内源性和异种生物代谢物分析的加速器质谱（AMS）使用定量核磁共振（NMR）和液相色谱耦合电感耦合等离子体质谱（LC-ICP-MS）进行代谢物分析。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Xenobiotica 医学-毒理学

CiteScore

3.80

自引率

5.60%

发文量

审稿时长

2 months

期刊介绍： Xenobiotica covers seven main areas, including:General Xenobiochemistry, including in vitro studies concerned with the metabolism, disposition and excretion of drugs, and other xenobiotics, as well as the structure, function and regulation of associated enzymesClinical Pharmacokinetics and Metabolism, covering the pharmacokinetics and absorption, distribution, metabolism and excretion of drugs and other xenobiotics in manAnimal Pharmacokinetics and Metabolism, covering the pharmacokinetics, and absorption, distribution, metabolism and excretion of drugs and other xenobiotics in animalsPharmacogenetics, defined as the identification and functional characterisation of polymorphic genes that encode xenobiotic metabolising enzymes and transporters that may result in altered enzymatic, cellular and clinical responses to xenobioticsMolecular Toxicology, concerning the mechanisms of toxicity and the study of toxicology of xenobiotics at the molecular levelXenobiotic Transporters, concerned with all aspects of the carrier proteins involved in the movement of xenobiotics into and out of cells, and their impact on pharmacokinetic behaviour in animals and manTopics in Xenobiochemistry, in the form of reviews and commentaries are primarily intended to be a critical analysis of the issue, wherein the author offers opinions on the relevance of data or of a particular experimental approach or methodology