Do depressive and anxiety symptoms influence the construct validity of Multiple Sclerosis Walking Scale-12 scores?

IF 16.4 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Accounts of Chemical Research Pub Date : 2024-05-01 Epub Date: 2024-01-01 DOI:10.1037/rep0000534

Petra Šilić, Catherine D Jones, Brenda Jeng, Robert W Motl

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引用次数: 0

Abstract

Purpose/objective: Walking dysfunction, depression, and anxiety are prevalent, burdensome, and interrelated outcomes in persons with multiple sclerosis (MS). The 12-item Multiple Sclerosis Walking Scale (MSWS-12) is a common patient-reported outcome (PRO) of walking dysfunction in research and practice involving MS, but the construct validity of its scores might be influenced by symptoms of depression and anxiety. This study examined if symptoms of depression and anxiety influenced the construct validity of MSWS-12 scores.

Research method/design: The sample included 189 participants with MS who completed the MSWS-12, Hospital Anxiety and Depression Scale (HADS-Depression subscale [HADS-D] and HADS-Anxiety subscale [HADS-A]), 6-minute walk (6MW), and timed 25-foot walk (T25FW). We conducted bivariate correlation analysis to examine the associations between MSWS-12 scores and both the 6MW and T25FW, while controlling for HADS-D and HADS-A scores.

Results: MSWS-12 scores were significantly correlated with the 6MW (r = -.752), T25FW (r = .694), HADS-D (r = .405), and HADS-A (r = .235). The correlations between MSWS-12 and 6MW (pr = -.725) and T25FW (pr = .685) did not change when controlling for HADS-D and HADS-A scores. The correlations between MSWS-12 and 6MW (r = -.708 and r = -.726) and T25FW (r = .687 and r = .748) were strong in subsamples with elevated HADS-D and HADS-A scores.

Conclusions/implications: Our results strengthen the validity evidence for MSWS-12 scores as a PRO of walking dysfunction in MS, including among those with symptoms of depression and anxiety. (PsycInfo Database Record (c) 2024 APA, all rights reserved).

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抑郁和焦虑症状是否会影响多发性硬化症步行量表-12 评分的构建有效性？

目的/目标：行走功能障碍、抑郁和焦虑是多发性硬化症（MS）患者普遍存在的、负担沉重且相互关联的结果。在涉及多发性硬化症的研究和实践中，12 项多发性硬化症行走量表（MSWS-12）是一种常见的患者报告的行走功能障碍结果（PRO），但其得分的构建有效性可能会受到抑郁和焦虑症状的影响。本研究探讨了抑郁和焦虑症状是否会影响 MSWS-12 评分的结构效度：样本包括 189 名完成 MSWS-12、医院焦虑抑郁量表（HADS-抑郁分量表 [HADS-D] 和 HADS-焦虑分量表 [HADS-A]）、6 分钟步行（6MW）和 25 英尺定时步行（T25FW）的多发性硬化症患者。在控制 HADS-D 和 HADS-A 评分的前提下，我们进行了双变量相关分析，以研究 MSWS-12 评分与 6MW 和 T25FW 之间的关联：结果：MSWS-12 分数与 6MW (r = -.752)、T25FW (r = .694)、HADS-D (r = .405) 和 HADS-A (r = .235) 有明显相关性。在控制 HADS-D 和 HADS-A 评分后，MSWS-12 与 6MW (pr = -.725) 和 T25FW (pr = .685) 之间的相关性没有变化。在HADS-D和HADS-A评分升高的子样本中，MSWS-12与6MW（r = -.708 和 r = -.726）和T25FW（r = .687和r = .748）之间的相关性很强：我们的研究结果加强了 MSWS-12 评分作为多发性硬化症患者（包括伴有抑郁和焦虑症状的患者）行走功能障碍 PRO 的有效性证据。(PsycInfo Database Record (c) 2024 APA，保留所有权利）。

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来源期刊

Accounts of Chemical Research 化学-化学综合

CiteScore

31.40

自引率

1.10%

发文量

312

审稿时长

2 months

期刊介绍： Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.