The role of CSTF2 in cancer: from technology to clinical application.

IF 3.4 3区生物学 Q3 CELL BIOLOGY

Cell Cycle Pub Date : 2023-12-01 Epub Date: 2024-01-02 DOI:10.1080/15384101.2023.2299624

Jiaxiang Ding, Yue Su, Youru Liu, Yuanyuan Xu, Dashuai Yang, Xuefeng Wang, Shuli Hao, Huan Zhou, Hongtao Li

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Abstract

A protein called cleavage-stimulating factor subunit 2 (CSTF2, additionally called CSTF-64) binds RNA and is needed for the cleavage and polyadenylation of mRNA. CSTF2 is an important component subunit of the cleavage stimulating factor (CSTF), which is located on the X chromosome and encodes 557 amino acids. There is compelling evidence linking elevated CSTF2 expression to the pathological advancement of cancer and on its impact on the clinical aspects of the disease. The progression of cancers, including hepatocellular carcinoma, melanoma, prostate cancer, breast cancer, and pancreatic cancer, is correlated with the upregulation of CSTF2 expression. This review provides a fresh perspective on the investigation of the associations between CSTF2 and various malignancies and highlights current studies on the regulation of CSTF2. In particular, the mechanism of action and potential clinical applications of CSTF2 in cancer suggest that CSTF2 can serve as a new biomarker and individualized treatment target for a variety of cancer types.

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CSTF2 在癌症中的作用：从技术到临床应用。

一种名为裂解刺激因子亚基 2（CSTF2，又称 CSTF-64）的蛋白质与 RNA 结合，是 mRNA 的裂解和多聚腺苷酸化所必需的。CSTF2 是裂解刺激因子（CSTF）的一个重要组成亚基，CSTF 位于 X 染色体上，编码 557 个氨基酸。有令人信服的证据表明，CSTF2 表达的升高与癌症的病理进展及其对疾病临床方面的影响有关。肝细胞癌、黑色素瘤、前列腺癌、乳腺癌和胰腺癌等癌症的进展与 CSTF2 表达的上调有关。本综述以全新的视角探讨了 CSTF2 与各种恶性肿瘤之间的关联，并重点介绍了目前有关 CSTF2 调控的研究。特别是 CSTF2 在癌症中的作用机制和潜在临床应用表明，CSTF2 可作为一种新的生物标记物和个体化治疗靶点，用于多种癌症类型。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Cell Cycle 生物-细胞生物学

CiteScore

7.70

自引率

2.30%

发文量

281

审稿时长

1 months

期刊介绍： Cell Cycle is a bi-weekly peer-reviewed journal of high priority research from all areas of cell biology. Cell Cycle covers all topics from yeast to man, from DNA to function, from development to aging, from stem cells to cell senescence, from metabolism to cell death, from cancer to neurobiology, from molecular biology to therapeutics. Our goal is fast publication of outstanding research.