Environmental Enrichment for Stroke and Traumatic Brain Injury: Mechanisms and Translational Implications.

IF 4.2 2区 医学 Q1 PHYSIOLOGY
Luwei Nie, Jinxin He, Junmin Wang, Ruike Wang, Leo Huang, Lin Jia, Yun Tai Kim, Ujjal K Bhawal, Xiaochong Fan, Marietta Zille, Chao Jiang, Xuemei Chen, Jian Wang
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引用次数: 0

Abstract

Acquired brain injuries, such as ischemic stroke, intracerebral hemorrhage (ICH), and traumatic brain injury (TBI), can cause severe neurologic damage and even death. Unfortunately, currently, there are no effective and safe treatments to reduce the high disability and mortality rates associated with these brain injuries. However, environmental enrichment (EE) is an emerging approach to treating and rehabilitating acquired brain injuries by promoting motor, sensory, and social stimulation. Multiple preclinical studies have shown that EE benefits functional recovery, including improved motor and cognitive function and psychological benefits mediated by complex protective signaling pathways. This article provides an overview of the enriched environment protocols used in animal models of ischemic stroke, ICH, and TBI, as well as relevant clinical studies, with a particular focus on ischemic stroke. Additionally, we explored studies of animals with stroke and TBI exposed to EE alone or in combination with multiple drugs and other rehabilitation modalities. Finally, we discuss the potential clinical applications of EE in future brain rehabilitation therapy and the molecular and cellular changes caused by EE in rodents with stroke or TBI. This article aims to advance preclinical and clinical research on EE rehabilitation therapy for acquired brain injury. © 2024 American Physiological Society. Compr Physiol 14:5291-5323, 2024.

中风和创伤性脑损伤的环境富集:机制与转化影响》。
后天性脑损伤,如缺血性中风、脑内出血(ICH)和创伤性脑损伤(TBI),可导致严重的神经损伤,甚至死亡。遗憾的是,目前还没有有效和安全的治疗方法来降低与这些脑损伤相关的高致残率和死亡率。然而,通过促进运动、感官和社交刺激,丰富环境(EE)是治疗和康复后天性脑损伤的一种新兴方法。多项临床前研究表明,EE 有利于功能恢复,包括通过复杂的保护性信号通路改善运动和认知功能以及心理益处。本文概述了用于缺血性中风、ICH 和创伤性脑损伤动物模型的富集环境方案以及相关临床研究,尤其侧重于缺血性中风。此外,我们还探讨了对中风和创伤性脑损伤动物单独或与多种药物和其他康复方式结合使用 EE 的研究。最后,我们讨论了 EE 在未来脑康复治疗中的潜在临床应用,以及 EE 在中风或创伤性脑损伤啮齿动物中引起的分子和细胞变化。本文旨在推动后天性脑损伤 EE 康复疗法的临床前和临床研究。© 2024 美国生理学会。Compr Physiol 14:5291-5323, 2024.
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来源期刊
CiteScore
10.50
自引率
0.00%
发文量
38
审稿时长
6-12 weeks
期刊介绍: Comprehensive Physiology is the most authoritative and comprehensive collection of physiology information ever assembled, and uses the most powerful features of review journals and electronic reference works to cover the latest key developments in the field, through the most authoritative articles on the subjects covered. This makes Comprehensive Physiology a valued reference work on the evolving science of physiology for both researchers and clinicians. It also provides a useful teaching tool for instructors and an informative resource for medical students and other students in the life and health sciences.
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